Effect of Active Metabolites of Chlordiazepoxide and Diazepam, Alone or in Combination with Alcohol, on Psychomotor Skills Related to Driving
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Interaction of the main metabolites of diazepam and chlordiazepoxide with alcohol was measured in two subacute double-blind cross-over experiments on 40 healthy, young volunteers. The drugs were administered for two week periods. The variables measured were choice reaction time and accuracy, eye-hand co-ordination, divided attention, flicker fusion, proprioception and nystagmus. Chlordiazepoxide lactam, methyloxazepam and oxazepam significantly enhanced the alcohol-induced impairment of psychomotor skills, whereas N-desmethyl-diazepam did so only exceptionally in certain subjects in the choice reaction test. It is concluded that diazepam-alcohol interaction on psychomotor skills is mainly due to the parent compound. No correlation between the serum level of the agents and the changes in performance were found.
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PMID: 39634377 PMC: 11615539. DOI: 10.1016/j.rcsop.2024.100538.
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