Development and Characterization of Gentamicin-Loaded Arabinoxylan-Sodium Alginate Films As Antibacterial Wound Dressing

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2022 Mar 10

PMID 35270041

Authors

Abdulaziz I Alzarea

Nabil K Alruwaili

Muhammad Masood Ahmad

Muhammad Usman Munir

Adeel Masood Butt

Ziyad A Alrowaili

Muhammad Syafiq Bin Shahari

Ziyad S Almalki

Saad S Alqahtani

Anton V Dolzhenko

Naveed Ahmad

Affiliations

Soon will be listed here.

Abstract

Biopolymer-based antibacterial films are attractive materials for wound dressing application because they possess chemical, mechanical, exudate absorption, drug delivery, antibacterial, and biocompatible properties required to support wound healing. Herein, we fabricated and characterized films composed of arabinoxylan (AX) and sodium alginate (SA) loaded with gentamicin sulfate (GS) for application as a wound dressing. The FTIR, XRD, and thermal analyses show that AX, SA, and GS interacted through hydrogen bonding and were thermally stable. The AXSA film displays desirable wound dressing characteristics: transparency, uniform thickness, smooth surface morphology, tensile strength similar to human skin, mild water/exudate uptake capacity, water transmission rate suitable for wound dressing, and excellent cytocompatibility. In Franz diffusion release studies, >80% GS was released from AXSA films in two phases in 24 h following the Fickian diffusion mechanism. In disk diffusion assay, the AXSA films demonstrated excellent antibacterial effect against E.coli, S. aureus, and P. aeruginosa. Overall, the findings suggest that GS-loaded AXSA films hold potential for further development as antibacterial wound dressing material.

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