Damage-Associated Molecular Patterns (DAMPs) in Retinal Disorders

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2022 Mar 10

PMID 35269741

Authors

Binapani Mahaling

Shermaine W Y Low

Molly Beck

Devesh Kumar

Simrah Ahmed

Thomas B Connor

Baseer Ahmad

Shyam S Chaurasia

Affiliations

Soon will be listed here.

Abstract

Damage-associated molecular patterns (DAMPs) are endogenous danger molecules released from the extracellular and intracellular space of damaged tissue or dead cells. Recent evidence indicates that DAMPs are associated with the sterile inflammation caused by aging, increased ocular pressure, high glucose, oxidative stress, ischemia, mechanical trauma, stress, or environmental conditions, in retinal diseases. DAMPs activate the innate immune system, suggesting their role to be protective, but may promote pathological inflammation and angiogenesis in response to the chronic insult or injury. DAMPs are recognized by specialized innate immune receptors, such as receptors for advanced glycation end products (RAGE), toll-like receptors (TLRs) and the NOD-like receptor family (NLRs), and purine receptor 7 (P2X7), in systemic diseases. However, studies describing the role of DAMPs in retinal disorders are meager. Here, we extensively reviewed the role of DAMPs in retinal disorders, including endophthalmitis, uveitis, glaucoma, ocular cancer, ischemic retinopathies, diabetic retinopathy, age-related macular degeneration, rhegmatogenous retinal detachment, proliferative vitreoretinopathy, and inherited retinal disorders. Finally, we discussed DAMPs as biomarkers, therapeutic targets, and therapeutic agents for retinal disorders.

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References

Windisch B, LeVatte T, Archibald M, Chauhan B . Induction of heat shock proteins 27 and 72 in retinal ganglion cells after acute pressure-induced ischaemia. Clin Exp Ophthalmol. 2009; 37(3):299-307. DOI: 10.1111/j.1442-9071.2009.02032.x. View

Lewden O, GARCHER C, Assem M, Morales C, Rochette L, Bron A . Changes of the inducible heat shock protein 70 mRNA level in rat retina after ischemia and reperfusion. Ophthalmic Res. 1998; 30(5):291-4. DOI: 10.1159/000055487. View

Wiemann S, Yousf A, Joachim S, Peters C, Mueller-Buehl A, Wagner N . Knock-Out of Tenascin-C Ameliorates Ischemia-Induced Rod-Photoreceptor Degeneration and Retinal Dysfunction. Front Neurosci. 2021; 15:642176. PMC: 8172977. DOI: 10.3389/fnins.2021.642176. View

Zhang Y, Zhao Z, Zhao X, Xie H, Zhang C, Sun X . HMGB2 causes photoreceptor death via down-regulating Nrf2/HO-1 and up-regulating NF-κB/NLRP3 signaling pathways in light-induced retinal degeneration model. Free Radic Biol Med. 2022; 181:14-28. DOI: 10.1016/j.freeradbiomed.2022.01.018. View

Faingold D, Marshall J, Antecka E, Di Cesare S, Odashiro A, Bakalian S . Immune expression and inhibition of heat shock protein 90 in uveal melanoma. Clin Cancer Res. 2008; 14(3):847-55. DOI: 10.1158/1078-0432.CCR-07-0926. View

Yeo J, Sadeghi J, Campochiaro P, Green W, Glaser B . Intravitreous fibronectin and platelet-derived growth factor. New model for traction retinal detachment. Arch Ophthalmol. 1986; 104(3):417-21. DOI: 10.1001/archopht.1986.01050150119041. View

Takahashi T, Kulkarni N, Lee E, Zhang L, Wong G, Gallo R . Cathelicidin promotes inflammation by enabling binding of self-RNA to cell surface scavenger receptors. Sci Rep. 2018; 8(1):4032. PMC: 5838106. DOI: 10.1038/s41598-018-22409-3. View

Dinet V, Bruban J, Chalour N, Maoui A, An N, Jonet L . Distinct effects of inflammation on gliosis, osmohomeostasis, and vascular integrity during amyloid beta-induced retinal degeneration. Aging Cell. 2012; 11(4):683-93. DOI: 10.1111/j.1474-9726.2012.00834.x. View

Wu J, Zhang S, Nickerson J, Gao F, Sun Z, Chen X . Cumulative mtDNA damage and mutations contribute to the progressive loss of RGCs in a rat model of glaucoma. Neurobiol Dis. 2014; 74:167-179. PMC: 4523228. DOI: 10.1016/j.nbd.2014.11.014. View

10.

Wang W, McNatt L, Pang I, Hellberg P, Fingert J, McCartney M . Increased expression of serum amyloid A in glaucoma and its effect on intraocular pressure. Invest Ophthalmol Vis Sci. 2008; 49(5):1916-23. DOI: 10.1167/iovs.07-1104. View

11.

Vallejo-Garcia J, Asencio-Duran M, Pastora-Salvador N, Vinciguerra P, Romano M . Role of inflammation in endophthalmitis. Mediators Inflamm. 2012; 2012:196094. PMC: 3438776. DOI: 10.1155/2012/196094. View

12.

Kothari P, Marass F, Yang J, Stewart C, Stephens D, Patel J . Cell-free DNA profiling in retinoblastoma patients with advanced intraocular disease: An MSKCC experience. Cancer Med. 2020; 9(17):6093-6101. PMC: 7476838. DOI: 10.1002/cam4.3144. View

13.

Yoneda S, Hara H, Hirata A, Fukushima M, Inomata Y, Tanihara H . Vitreous fluid levels of beta-amyloid((1-42)) and tau in patients with retinal diseases. Jpn J Ophthalmol. 2005; 49(2):106-8. DOI: 10.1007/s10384-004-0156-x. View

14.

Swaney J, Moreno K, Gentile A, Sabbadini R, Stoller G . Sphingosine-1-phosphate (S1P) is a novel fibrotic mediator in the eye. Exp Eye Res. 2008; 87(4):367-75. DOI: 10.1016/j.exer.2008.07.005. View

15.

Wang L, Feng Y, Cheng Y . Effect on proliferation and apoptosis of retinoblastoma cell by RNA inhibiting high mobility group protein box-1 expression. Int J Ophthalmol. 2017; 10(1):30-34. PMC: 5225345. DOI: 10.18240/ijo.2017.01.05. View

16.

Hangai M, Yoshimura N, Yoshida M, Yabuuchi K, Honda Y . Interleukin-1 gene expression in transient retinal ischemia in the rat. Invest Ophthalmol Vis Sci. 1995; 36(3):571-8. View

17.

Smith W, Mitchell P, Leeder S, Wang J . Plasma fibrinogen levels, other cardiovascular risk factors, and age-related maculopathy: the Blue Mountains Eye Study. Arch Ophthalmol. 1998; 116(5):583-7. DOI: 10.1001/archopht.116.5.583. View

18.

Bresnick A, Weber D, Zimmer D . S100 proteins in cancer. Nat Rev Cancer. 2015; 15(2):96-109. PMC: 4369764. DOI: 10.1038/nrc3893. View

19.

Jin E, Burnier J . Liquid Biopsy in Uveal Melanoma: Are We There Yet?. Ocul Oncol Pathol. 2021; 7(1):1-16. PMC: 7989728. DOI: 10.1159/000508613. View

20.

Zhu D, Wang Y, Zou C, She X, Zheng Z . The role of uric acid in the pathogenesis of diabetic retinopathy based on Notch pathway. Biochem Biophys Res Commun. 2018; 503(2):921-929. DOI: 10.1016/j.bbrc.2018.06.097. View