Abdominal Aortic Calcification and Cardiovascular Outcomes in Chronic Kidney Disease: Findings from KNOW-CKD Study

Overview

Journal J Clin Med

Specialty General Medicine

Date 2022 Mar 10

PMID 35268249

Authors

Sang Heon Suh

Tae Ryom Oh

Hong Sang Choi

Chang Seong Kim

Eun Hui Bae

Kook-Hwan Oh

Joongyub Lee

Yun Kyu Oh

Ji Yong Jung

Seong Kwon Ma

Soo Wan Kim

The Korean Cohort Study For Outcomes In Patients With Chronic Kidney Disease Know-Ckd Investigators

Affiliations

Soon will be listed here.

Abstract

To investigate the association between abdominal aortic calcification score (AACS) assessed by plain radiograph of the lateral abdomen and the risk of cardiovascular (CV) events in patients with pre-dialysis chronic kidney disease (CKD), a total of 2090 pre-dialysis CKD patients from the Korean Cohort Study for Outcome in Patients with Chronic Kidney Disease (KNOW-CKD) were categorized by AACS into 0, 1-2, 3-4, 5-6, and ≥7. The primary outcome of the study was the composite CV events, defined as a composite of non-fatal CV events and all-cause death. The risk of composite CV events was significantly higher in the subjects with AACS ≥ 7 (adjusted hazard ratio (HR) 1.888, 95% confidence interval (CI) 1.219 to 2.923), compared to that of the subjects with AACS 0. The risks of fatal and non-fatal CV events (adjusted HR 1.052, 95% CI 1.030 to 1.073) and all-cause death (adjusted HR 1.949, 95% CI 1.073 to 3.539) were also significantly higher in the subjects with AACS ≥ 7. In conclusion, AACS assessed by plain radiograph is independently associated with adverse CV outcomes in patients with pre-dialysis CKD. A simple radiographic examination of the lateral abdomen may help CV risk stratification in this population.

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