Polysaccharide-Drug Conjugates: A Tool for Enhanced Cancer Therapy

Overview

Journal Polymers (Basel)

Publisher MDPI

Date 2022 Mar 10

PMID 35267773

Authors

Neena Yadav

Arul Prakash Francis

Veeraraghavan Vishnu Priya

Shankargouda Patil

Shazia Mustaq

Sameer Saeed Khan

Khalid J Alzahrani

Hamsa Jameel Banjer

Surapaneni Krishna Mohan

Ullas Mony

Rukkumani Rajagopalan

Affiliations

Soon will be listed here.

Abstract

Cancer is one of the most widespread deadly diseases, following cardiovascular disease, worldwide. Chemotherapy is widely used in combination with surgery, hormone and radiation therapy to treat various cancers. However, chemotherapeutic drugs can cause severe side effects due to non-specific targeting, poor bioavailability, low therapeutic indices, and high dose requirements. Several drug carriers successfully overcome these issues and deliver drugs to the desired sites, reducing the side effects. Among various drug delivery systems, polysaccharide-based carriers that target only the cancer cells have been developed to overcome the toxicity of chemotherapeutics. Polysaccharides are non-toxic, biodegradable, hydrophilic biopolymers that can be easily modified chemically to improve the bioavailability and stability for delivering therapeutics into cancer tissues. Different polysaccharides, such as chitosan, alginates, cyclodextrin, pullulan, hyaluronic acid, dextran, guar gum, pectin, and cellulose, have been used in anti-cancer drug delivery systems. This review highlights the recent progress made in polysaccharides-based drug carriers in anti-cancer therapy.

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