Co-infection of Human Papillomavirus and Other Sexually Transmitted Bacteria in Cervical Cancer Patients in the Philippines

Overview

Journal Gynecol Oncol Rep

Publisher Elsevier

Date 2022 Mar 10

PMID 35265741

Authors

Ourlad Alzeus G Tantengco

Yukiko Nakura

Michinobu Yoshimura

Fumiko Nishiumi

Erlidia F Llamas-Clark

Itaru Yanagihara

Affiliations

Soon will be listed here.

Abstract

Cervical cancer is the fourth most common cancer in women globally. Based on several epidemiologic studies, human papillomavirus is strongly associated with cervical neoplasia. Aside from HPV, other bacterial infections in the genital tract were associated with cervical neoplasia. This study aimed to determine the prevalence of HPV infection; and co-infection with spp., spp., and in Filipino cervical cancer patients. Forty-four patients (28 patients with cervical carcinoma and 16 patients with non-malignant cervix) who consulted in the Philippine General Hospital from 2016 to 2017 were included in this study. HPV genotyping and genetic detection of spp., spp., and were done using different PCR assays. The prevalence of HPV 16/18/33/52 was 75% in cervical cancer patients and 25% in control patients. Infection with HPV 16/18/33/52 was significantly associated with having cervical cancer (OR: 9.00; 95% CI: 2.18-37.18; = 0.0024). HPV-16 was the most prevalent HPV genotype among Filipino cervical cancer patients. HPV-18 and HPV-52 were only detected from cervical cancer patients. Among HPV-positive patients, we noted a 22.73% co-infection with spp. and 9.09% co-infection with spp. To our knowledge, this is the first study on the co-infection of HPV and sexually transmitted infections among cervical cancer patients in the Philippines.

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