Clinical Efficacy of Percutaneous Kyphoplasty Combined with Calcitriol and Calcium in the Treatment of Traumatic Nonosteoporotic Vertebral Compression Fractures

Overview

Journal Pain Res Manag

Date 2022 Mar 10

PMID 35265233

Authors

Shouqian Dai

Xin Lu

Ningning Dai

Xiu Shi

Peng Yang

Peng Peng

Feng Xu

Affiliations

Soon will be listed here.

Abstract

Objective: The present study investigated the clinical efficacy of percutaneous kyphoplasty (PKP) combined with calcitriol and calcium in the treatment of traumatic nonosteoporotic vertebral compression fractures (TNVCFs).

Methods: The patients were equally divided into a control group and a treatment group by a random number table. The patients in the control group underwent PKP surgery, and the patients in the treatment group received calcitriol and calcium on the basis of PKP surgery. The visual analog scale (VAS) pain scores, Oswestry Disability Index (ODI) scores, the height of the anterior edge of the vertebral body, Cobb's angle, and the level of the bone mineral density of the two groups of TNVCF patients before surgery were recorded and compared, one and six months after surgery.

Results: Thirty-six inpatients with TNVCFs admitted to the trauma center of the First Affiliated Hospital of Soochow University from January 2019 to January 2020 were recruited. There were no significant differences in the VAS and ODI scores, the height of the anterior edge of the injured vertebral body, Cobb's angle, and bone mineral density between the two groups before surgery ( > 0.05). The VAS scores, ODI scores, the height of the anterior edge of the injured vertebral body, and Cobb's angle of the two groups of patients after surgery were significantly better than those before surgery. One and six months after surgery, the VAS and ODI scores, the height of the anterior edge of the injured vertebral body, Cobb's angle, and the bone mineral density of the patients in the treatment group improved significantly compared to those in the control group ( < 0.05).

Conclusions: PKP combined with calcitriol and calcium medications could significantly relieve pain, alleviate the loss of compressed vertebral height and kyphosis, and improve the spinal function and the life quality of the TNVCF patients.

References

Boonen S, Van Meirhaeghe J, Bastian L, Cummings S, Ranstam J, Tillman J . Balloon kyphoplasty for the treatment of acute vertebral compression fractures: 2-year results from a randomized trial. J Bone Miner Res. 2011; 26(7):1627-37. DOI: 10.1002/jbmr.364. View

Rizzoli R, Boonen S, Brandi M, Bruyere O, Cooper C, Kanis J . Vitamin D supplementation in elderly or postmenopausal women: a 2013 update of the 2008 recommendations from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO). Curr Med Res Opin. 2013; 29(4):305-13. DOI: 10.1185/03007995.2013.766162. View

Boonen S, Wahl D, Nauroy L, Brandi M, Bouxsein M, Goldhahn J . Balloon kyphoplasty and vertebroplasty in the management of vertebral compression fractures. Osteoporos Int. 2011; 22(12):2915-34. DOI: 10.1007/s00198-011-1639-5. View

Papanastassiou I, Phillips F, Van Meirhaeghe J, Berenson J, Andersson G, Chung G . Comparing effects of kyphoplasty, vertebroplasty, and non-surgical management in a systematic review of randomized and non-randomized controlled studies. Eur Spine J. 2012; 21(9):1826-43. PMC: 3459114. DOI: 10.1007/s00586-012-2314-z. View

Bouza C, Lopez-Cuadrado T, Almendro N, Amate J . Safety of balloon kyphoplasty in the treatment of osteoporotic vertebral compression fractures in Europe: a meta-analysis of randomized controlled trials. Eur Spine J. 2014; 24(4):715-23. DOI: 10.1007/s00586-014-3581-7. View

Du J, Li X, Lin X . Kyphoplasty versus vertebroplasty in the treatment of painful osteoporotic vertebral compression fractures: two-year follow-up in a prospective controlled study. Acta Orthop Belg. 2015; 80(4):477-86. View

Liu J, Li C, Chang C, Liao W . Long-term follow-up study of osteoporotic vertebral compression fracture treated using balloon kyphoplasty and vertebroplasty. J Neurosurg Spine. 2015; 23(1):94-8. DOI: 10.3171/2014.11.SPINE14579. View

Garfin S, Buckley R, Ledlie J . Balloon kyphoplasty for symptomatic vertebral body compression fractures results in rapid, significant, and sustained improvements in back pain, function, and quality of life for elderly patients. Spine (Phila Pa 1976). 2006; 31(19):2213-20. DOI: 10.1097/01.brs.0000232803.71640.ba. View

Jackson R, LaCroix A, Gass M, Wallace R, Robbins J, Lewis C . Calcium plus vitamin D supplementation and the risk of fractures. N Engl J Med. 2006; 354(7):669-83. DOI: 10.1056/NEJMoa055218. View

10.

Chen L, Yang H, Tang T . Unilateral versus bilateral balloon kyphoplasty for multilevel osteoporotic vertebral compression fractures: a prospective study. Spine (Phila Pa 1976). 2011; 36(7):534-40. DOI: 10.1097/BRS.0b013e3181f99d70. View

11.

Ahmed L, Center J, Bjornerem A, Bluic D, Joakimsen R, Jorgensen L . Progressively increasing fracture risk with advancing age after initial incident fragility fracture: the Tromsø study. J Bone Miner Res. 2013; 28(10):2214-21. DOI: 10.1002/jbmr.1952. View

12.

Lyles K, Schenck A, Colon-Emeric C . Hip and other osteoporotic fractures increase the risk of subsequent fractures in nursing home residents. Osteoporos Int. 2008; 19(8):1225-33. PMC: 2562901. DOI: 10.1007/s00198-008-0569-3. View

13.

Chung M, Balk E, Brendel M, Ip S, Lau J, Lee J . Vitamin D and calcium: a systematic review of health outcomes. Evid Rep Technol Assess (Full Rep). 2010; (183):1-420. PMC: 4781105. View

14.

Tang B, Eslick G, Nowson C, Smith C, Bensoussan A . Use of calcium or calcium in combination with vitamin D supplementation to prevent fractures and bone loss in people aged 50 years and older: a meta-analysis. Lancet. 2007; 370(9588):657-66. DOI: 10.1016/S0140-6736(07)61342-7. View

15.

Dai S, Qin R, Shi X, Yang H . Percutaneous vertebroplasty versus kyphoplasty for the treatment of neurologically intact osteoporotic Kümmell's disease. BMC Surg. 2021; 21(1):65. PMC: 7846985. DOI: 10.1186/s12893-021-01057-x. View

16.

Taylor R, Fritzell P, Taylor R . Balloon kyphoplasty in the management of vertebral compression fractures: an updated systematic review and meta-analysis. Eur Spine J. 2007; 16(8):1085-100. PMC: 2200787. DOI: 10.1007/s00586-007-0308-z. View

17.

Ledlie J, Renfro M . Balloon kyphoplasty: one-year outcomes in vertebral body height restoration, chronic pain, and activity levels. J Neurosurg. 2003; 98(1 Suppl):36-42. DOI: 10.3171/spi.2003.98.1.0036. View

18.

Bischoff-Ferrari H, Can U, Staehelin H, Platz A, Henschkowski J, Michel B . Severe vitamin D deficiency in Swiss hip fracture patients. Bone. 2008; 42(3):597-602. DOI: 10.1016/j.bone.2007.10.026. View

19.

Robinson Y, Olerud C . Vertebroplasty and kyphoplasty--a systematic review of cement augmentation techniques for osteoporotic vertebral compression fractures compared to standard medical therapy. Maturitas. 2012; 72(1):42-9. DOI: 10.1016/j.maturitas.2012.02.010. View

20.

Vanek P, Bradac O, Konopkova R, de Lacy P, Lacman J, Benes V . Treatment of thoracolumbar trauma by short-segment percutaneous transpedicular screw instrumentation: prospective comparative study with a minimum 2-year follow-up. J Neurosurg Spine. 2013; 20(2):150-6. DOI: 10.3171/2013.11.SPINE13479. View