Interstitial Lung Disease in Infancy and Early Childhood: a Clinicopathological Primer

Overview

Journal Eur Respir Rev

Specialty Pulmonary Medicine

Date 2022 Mar 10

PMID 35264412

Authors

Florian Peter Laenger

Nicolaus Schwerk

Jens Dingemann

Tobias Welte

Bernd Auber

Stijn Verleden

Maximilian Ackermann

Steven J Mentzer

Matthias Griese

Danny Jonigk

Affiliations

Soon will be listed here.

Abstract

Children's interstitial lung disease (chILD) encompasses a wide and heterogeneous spectrum of diseases substantially different from that of adults. Established classification systems divide chILD into conditions more prevalent in infancy and other conditions occurring at any age. This categorisation is based on a multidisciplinary approach including clinical, radiological, genetic and histological findings. The diagnostic evaluation may include lung biopsies if other diagnostic approaches failed to identify a precise chILD entity, or if severe or refractory respiratory distress of unknown cause is present. As the majority of children will be evaluated and diagnosed outside of specialist centres, this review summarises relevant clinical, genetic and histological findings of chILD to provide assistance in clinical assessment and rational diagnostics.

Citing Articles

Pediatric Diffuse Lung Disease in Infants: Imaging Findings and Histopathologic Correlation.

Ramirez-Suarez K, Martinez-Correa S, Tierradentro-Garcia L, White A, Medina Perez M, Otero H Radiographics. 2024; 44(11):e240022.

PMID: 39418186 PMC: 11580020. DOI: 10.1148/rg.240022.

The Clinical Approach to Interstitial Lung Disease in Childhood: A Narrative Review Article.

Drobnakova S, Vargova V, Barkai L Children (Basel). 2024; 11(8).

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An interdisciplinary consensus approach to pulmonary hypertension in developmental lung disease.

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Developmental lung disease in a cat associated with high probability of severe pulmonary hypertension: natural history, histopathology and genetic analysis.

Nebel Y, Williams K, Lyons L, Reinero C, Ferriani R, Toschi Corneliani R JFMS Open Rep. 2024; 10(1):20551169241249003.

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A rare presentation of childhood interstitial lung disease attributed to KDM3B gene mutation: a case report.

Benslimane Z, Yavuz S, Francis N Pan Afr Med J. 2024; 46:84.

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