Lack of Neutralizing Activity in Nonconvalescent Sera, Regardless of ABO Blood Group and Anti-A Isoagglutinin Titer

Overview

Journal J Clin Virol Plus

Specialty Microbiology

Date 2022 Mar 9

PMID 35262018

Authors

Daniele Focosi

Alfredo Rosellini

Pietro Giorgio Spezia

Lisa Macera

Maria Lanza

Aldo Paolicchi

Denise Biagini

Andreina Baj

Mauro Pistello

Fabrizio Maggi

Affiliations

Soon will be listed here.

Abstract

Background: Several ABO blood groups have been associated with the likelihood of infection, severity, and/or outcome of COVID-19 in hospitalized cohorts, raising the hypothesis that anti-A isoagglutinins in non-A-group recipients could act as neutralizing antibodies against SARS-CoV-2.

Materials And Methods: We run live virus neutralization tests using sera from 58 SARS-CoV-2 seronegative blood donors (27 O-group and 31 A-group) negatives for SARS-CoV-2 IgG to investigate what degree of neutralizing activity could be detected in their sera and eventual correlation with anti-A isoagglutinin titers.

Results: We could not find clinically relevant neutralizing activity in any blood group, regardless of anti-isoagglutinin titer.

Discussion: Our findings suggest that mechanisms other than neutralization explain the differences in outcomes from COVID19 seen in different ABO blood groups.

Citing Articles

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