Validation of a Novel Renal Denervation System With Cryoablation: A Preclinical Study and Case Series

Overview

Journal JACC Basic Transl Sci

Date 2022 Mar 8

PMID 35257036

Authors

Meng Ji

Han Chen

Li Shen

Yi Zhang

ZhiFeng Yao

Yizhe Wu

Yawei Xu

Junbo Ge

Affiliations

Soon will be listed here.

Abstract

Recently, we designed a renal denervation with cryoablation (Cryo-RDN) system using liquid nitrogen and proved its short-term safety and effectiveness. In this study, we first conducted a 6-month follow-up in a swine model. Renal sympathetic nerve activity remained at a significantly lower level than that of the control group after 6 months. In patients with resistant hypertension, Cryo-RDN demonstrated preliminary safety. Renal function fluctuations and vascular-related complications were not detected. In addition, the average 24-hour systolic and diastolic blood pressure decreased by 12.17 ± 8.35 mm Hg and 8.50 ± 3.83 mm Hg at the 6-month follow-up, respectively, compared with their baseline values.

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