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Assembly and Dynamics of the Actin Filament System in Nonmuscle Cells

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Journal J Cell Biochem
Date 1986 Jan 1
PMID 3525579
Citations 17
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Abstract

Kinetic analysis has provided a detailed quantitative description of the mechanism of actin polymerization as well as the methods to analyze the mechanisms of action of actin-binding proteins. In Acanthamoeba, five different proteins regulate the pool of monomers available for polymerization, cap the end of filaments, sever filaments, and cross-link filaments. Remarkably, many of these interactions involve very-low-affinity bonds between the protein molecules.

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