Enhancing Health Span: Muscle Stem Cells and Hormesis

Overview

Journal Biogerontology

Specialty Geriatrics

Date 2022 Mar 7

PMID 35254570

Authors

Edward J Calabrese

Vittorio Calabrese

Affiliations

Soon will be listed here.

Abstract

Sarcopenia is a significant public health and medical concern confronting the elderly. Considerable research is being directed to identify ways in which the onset and severity of sarcopenia may be delayed/minimized. This paper provides a detailed identification and assessment of hormetic dose responses in animal model muscle stem cells, with particular emphasis on cell proliferation, differentiation, and enhancing resilience to inflammatory stresses and how this information may be useful in preventing sarcopenia. Hormetic dose responses were observed following administration of a broad range of agents, including dietary supplements (e.g., resveratrol), pharmaceuticals (e.g., dexamethasone), endogenous ligands (e.g., tumor necrosis factor α), environmental contaminants (e.g., cadmium) and physical agents (e.g., low level laser). The paper assesses both putative mechanisms of hormetic responses in muscle stem cells, and potential therapeutic implications and application(s) of hormetic frameworks for slowing muscle loss and reduced functionality during the aging process.

Citing Articles

Exercise, hormesis and ageing: a new section in Biogerontology.

Radak Z, Rattan S Biogerontology. 2024; 26(1):26.

PMID: 39694926 DOI: 10.1007/s10522-024-10170-2.

The chemoprotective hormetic effects of rosmarinic acid.

Calabrese E, Pressman P, Wallace Hayes A, Dhawan G, Kapoor R, Agathokleous E Open Med (Wars). 2024; 19(1):20241065.

PMID: 39444791 PMC: 11497216. DOI: 10.1515/med-2024-1065.

Exposome on skeletal muscle system: a mini-review.

Purcaro C, Marramiero L, Santangelo C, Bondi D, Di Filippo E Eur J Appl Physiol. 2024; 124(8):2227-2233.

PMID: 38806941 PMC: 11322190. DOI: 10.1007/s00421-024-05515-1.

The Impact of Hormesis, Neuronal Stress Response, and Reproduction, upon Clinical Aging: A Narrative Review.

Kyriazis M, Swas L, Orlova T J Clin Med. 2023; 12(16).

PMID: 37629475 PMC: 10455615. DOI: 10.3390/jcm12165433.

Hormesis and Epidermal Stem Cells.

Calabrese E, Calabrese V Dose Response. 2022; 20(3):15593258221119911.

PMID: 36158736 PMC: 9500281. DOI: 10.1177/15593258221119911.

References

Abe M, CHAO T, Solway J, Rosner M, Hershenson M . Hydrogen peroxide stimulates mitogen-activated protein kinase in bovine tracheal myocytes: implications for human airway disease. Am J Respir Cell Mol Biol. 1994; 11(5):577-85. DOI: 10.1165/ajrcmb.11.5.7946386. View

Abrunhosa V, Soares C, Batista Possidonio A, Alvarenga A, Costa-Felix R, Costa M . Induction of skeletal muscle differentiation in vitro by therapeutic ultrasound. Ultrasound Med Biol. 2014; 40(3):504-12. DOI: 10.1016/j.ultrasmedbio.2013.10.013. View

Alvarez B, Quinn L, Busquets S, Quiles M, Lopez-Soriano F, Argiles J . Tumor necrosis factor-alpha exerts interleukin-6-dependent and -independent effects on cultured skeletal muscle cells. Biochim Biophys Acta. 2002; 1542(1-3):66-72. DOI: 10.1016/s0167-4889(01)00167-7. View

Anderson J . A role for nitric oxide in muscle repair: nitric oxide-mediated activation of muscle satellite cells. Mol Biol Cell. 2000; 11(5):1859-74. PMC: 14889. DOI: 10.1091/mbc.11.5.1859. View

Assis L, Moretti A, Abrahao T, de Souza H, Hamblin M, Parizotto N . Low-level laser therapy (808 nm) contributes to muscle regeneration and prevents fibrosis in rat tibialis anterior muscle after cryolesion. Lasers Med Sci. 2012; 28(3):947-55. PMC: 3521873. DOI: 10.1007/s10103-012-1183-3. View

Attele A, Zhou Y, Xie J, Wu J, Zhang L, Dey L . Antidiabetic effects of Panax ginseng berry extract and the identification of an effective component. Diabetes. 2002; 51(6):1851-8. DOI: 10.2337/diabetes.51.6.1851. View

Bosutti A, Degens H . The impact of resveratrol and hydrogen peroxide on muscle cell plasticity shows a dose-dependent interaction. Sci Rep. 2015; 5:8093. PMC: 4308712. DOI: 10.1038/srep08093. View

Calabrese E . Hormesis: why it is important to toxicology and toxicologists. Environ Toxicol Chem. 2008; 27(7):1451-74. DOI: 10.1897/07-541. View

Calabrese E . Toxicology rewrites its history and rethinks its future: giving equal focus to both harmful and beneficial effects. Environ Toxicol Chem. 2011; 30(12):2658-73. DOI: 10.1002/etc.687. View

10.

Calabrese E . Hormetic mechanisms. Crit Rev Toxicol. 2013; 43(7):580-606. DOI: 10.3109/10408444.2013.808172. View

11.

Calabrese E, Baldwin L . Chemical hormesis: its historical foundations as a biological hypothesis. Hum Exp Toxicol. 2000; 19(1):2-31. DOI: 10.1191/096032700678815585. View

12.

Calabrese E, Baldwin L . The marginalization of hormesis. Hum Exp Toxicol. 2000; 19(1):32-40. DOI: 10.1191/096032700678815594. View

13.

Calabrese E, Baldwin L . Radiation hormesis: its historical foundations as a biological hypothesis. Hum Exp Toxicol. 2000; 19(1):41-75. DOI: 10.1191/096032700678815602. View

14.

Calabrese E, Baldwin L . Radiation hormesis: the demise of a legitimate hypothesis. Hum Exp Toxicol. 2000; 19(1):76-84. DOI: 10.1191/096032700678815611. View

15.

Calabrese E, Baldwin L . Tales of two similar hypotheses: the rise and fall of chemical and radiation hormesis. Hum Exp Toxicol. 2000; 19(1):85-97. DOI: 10.1191/096032700678815620. View

16.

Calabrese E, Baldwin L . Defining hormesis. Hum Exp Toxicol. 2002; 21(2):91-7. DOI: 10.1191/0960327102ht217oa. View

17.

Calabrese E, Mattson M . Hormesis provides a generalized quantitative estimate of biological plasticity. J Cell Commun Signal. 2011; 5(1):25-38. PMC: 3058190. DOI: 10.1007/s12079-011-0119-1. View

18.

Calabrese E, Mattson M . How does hormesis impact biology, toxicology, and medicine?. NPJ Aging Mech Dis. 2017; 3:13. PMC: 5601424. DOI: 10.1038/s41514-017-0013-z. View

19.

Caporossi D, Ciafre S, Pittaluga M, Savini I, Farace M . Cellular responses to H(2)O(2) and bleomycin-induced oxidative stress in L6C5 rat myoblasts. Free Radic Biol Med. 2003; 35(11):1355-64. DOI: 10.1016/j.freeradbiomed.2003.08.008. View

20.

Cerletti M, Jang Y, Finley L, Haigis M, Wagers A . Short-term calorie restriction enhances skeletal muscle stem cell function. Cell Stem Cell. 2012; 10(5):515-9. PMC: 3561899. DOI: 10.1016/j.stem.2012.04.002. View