Structural Derivatization Strategies of Natural Phenols by Semi-synthesis and Total-synthesis

Overview

Journal Nat Prod Bioprospect

Publisher Springer

Specialty Biology

Date 2022 Mar 7

PMID 35254538

Authors

Ding Lin

Senze Jiang

Ailian Zhang

Tong Wu

Yongchang Qian

Qingsong Shao

Affiliations

Soon will be listed here.

Abstract

Structural derivatization of natural products has been a continuing and irreplaceable source of novel drug leads. Natural phenols are a broad category of natural products with wide pharmacological activity and have offered plenty of clinical drugs. However, the structural complexity and wide variety of natural phenols leads to the difficulty of structural derivatization. Skeleton analysis indicated most types of natural phenols can be structured by the combination and extension of three common fragments containing phenol, phenylpropanoid and benzoyl. Based on these fragments, the derivatization strategies of natural phenols were unified and comprehensively analyzed in this review. In addition to classical methods, advanced strategies with high selectivity, efficiency and practicality were emphasized. Total synthesis strategies of typical fragments such as stilbenes, chalcones and flavonoids were also covered and analyzed as the supplementary for supporting the diversity-oriented derivatization of natural phenols.

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