Gut Microbiome and the Role of Metabolites in the Study of Graves' Disease

Overview

Journal Front Mol Biosci

Specialty Biology

Date 2022 Mar 7

PMID 35252357

Authors

Haihua Liu

Huiying Liu

Chang Liu

Mengxue Shang

Tianfu Wei

Peiyuan Yin

Affiliations

Soon will be listed here.

Abstract

Graves' disease (GD) is an autoimmune thyroid disease (AITD), which is one of the most common organ-specific autoimmune disorders with an increasing prevalence worldwide. But the etiology of GD is still unclear. A growing number of studies show correlations between gut microbiota and GD. The dysbiosis of gut microbiota may be the reason for the development of GD by modulating the immune system. Metabolites act as mediators or modulators between gut microbiota and thyroid. The purpose of this review is to summarize the correlations between gut microbiota, microbial metabolites and GD. Challenges in the future study are also discussed. The combination of microbiome and metabolome may provide new insight for the study and put forward the diagnosis, treatment, prevention of GD in the future.

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