Insulin Receptors: Structure and Function

Overview

Journal Experientia

Specialty Science

Date 1986 Jul 15

PMID 3525209

Citations 4

Authors

E Van Obberghen

S Gammeltoft

Affiliations

Soon will be listed here.

Abstract

The recent characterization of the human insulin receptor structure and its intrinsic tyrosine kinase activity represent major advances in our understanding of the mechanism of insulin action. It is reasonable to think that the insulin-induced autophosphorylation and activation of its receptor kinase represent an important event in the action of insulin on cell metabolism and growth. The fundamental research reviewed may be followed by the discovery of molecular receptor defects in clinical syndromes of insulin resistance.

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