Metabolic and Endocrine Responses to Graded Exercise Under Acute Hypoxia

Overview

Journal Eur J Appl Physiol Occup Physiol

Specialty Occupational Medicine

Date 1986 Jan 1

PMID 3525153

Citations 8

Authors

P BOUISSOU

F Peronnet

G Brisson

R Helie

M LeDoux

Affiliations

Soon will be listed here.

Abstract

Eight male subjects (24 +/- 1 years old) performed graded ergocycle exercises in normoxic (N) and acute hypoxic (H) conditions (14.5% O2). VO2max decreased from 55.5 +/- 1.3 to 45.8 +/- 1.4 ml . kg-1 . min-1 in H condition. Plasma glucose and free fatty acid concentrations remained unchanged throughout exercise in both conditions. Increase in blood lactate concentration was associated with relative workload in both conditions. At VO2max lactate concentrations were similar in the two conditions, plasma insulin, glucagon, and LH concentrations did not significantly change in either. Plasma delta 4-androstenedione and testosterone increased in a similar manner in both conditions. Finally plasma norepinephrine concentration reached at VO2max was significantly lower in hypoxia. These results suggest that acute moderate hypoxia does not affect metabolic and hormonal responses to short exercise performed at similar relative workloads, i.e. when the reduction of VO2max due to hypoxia is taken into consideration. The lower catecholamine response to maximal exercise under acute hypoxia might suggest that the sympathetic response could be related to relative as well as absolute workloads.

Citing Articles

The role of exercise and hypoxia on glucose transport and regulation.

Soo J, Raman A, Lawler N, Goods P, Deldicque L, Girard O Eur J Appl Physiol. 2023; 123(6):1147-1165.

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Impact of hypoxia on male reproductive functions.

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Limitation of Maximal Heart Rate in Hypoxia: Mechanisms and Clinical Importance.

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Blood hormones as markers of training stress and overtraining.

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References

Keizer H, Poortman J, Bunnik G . Influence of physical exercise on sex-hormone metabolism. J Appl Physiol Respir Environ Exerc Physiol. 1980; 48(5):765-9. DOI: 10.1152/jappl.1980.48.5.765. View

Hesse B, Kanstrup I, Christensen N, Ingemann-Hansen T, Hansen J, Halkjaer-Kristensen J . Reduced norepinephrine response to dynamic exercise in human subjects during O2 breathing. J Appl Physiol Respir Environ Exerc Physiol. 1981; 51(1):176-8. DOI: 10.1152/jappl.1981.51.1.176. View

Linnarsson D, Karlsson J, Fagraeus L, Saltin B . Muscle metabolites and oxygen deficit with exercise in hypoxia and hyperoxia. J Appl Physiol. 1974; 36(4):399-402. DOI: 10.1152/jappl.1974.36.4.399. View

Bloom S, Johnson R, Park D, Rennie M, Sulaiman W . Differences in the metabolic and hormonal response to exercise between racing cyclists and untrained individuals. J Physiol. 1976; 258(1):1-18. PMC: 1308956. DOI: 10.1113/jphysiol.1976.sp011403. View

Knuttgen H, Saltin B . Oxygen uptake, muscle high-energy phosphates, and lactate in exercise under acute hypoxic conditions in man. Acta Physiol Scand. 1973; 87(3):368-76. DOI: 10.1111/j.1748-1716.1973.tb05401.x. View

Humpeler E, Skrabal F, Bartsch G . Influence of exposure to moderate altitude on the plasma concentraton of cortisol, aldosterone, renin, testosterone, and gonadotropins. Eur J Appl Physiol Occup Physiol. 1980; 45(2-3):167-76. DOI: 10.1007/BF00421324. View

PINELLI A . A new colorimetric method for plasma fatty acid analysis. Clin Chim Acta. 1973; 44(3):385-90. DOI: 10.1016/0009-8981(73)90082-x. View

SURKS M, CHINN K, MATOUSH L . Alterations in body composition in man after acute exposure to high altitude. J Appl Physiol. 1966; 21(6):1741-6. DOI: 10.1152/jappl.1966.21.6.1741. View

Escourrou P, Johnson D, Rowell L . Hypoxemia increases plasma catecholamine concentrations in exercising humans. J Appl Physiol Respir Environ Exerc Physiol. 1984; 57(5):1507-11. DOI: 10.1152/jappl.1984.57.5.1507. View

10.

Byrnes W, Mihevic P, Freedson P, Horvath S . Submaximal exercise quantified as percent of normoxic and hyperoxic maximum oxygen uptakes. Med Sci Sports Exerc. 1984; 16(6):572-7. View

11.

Kuoppasalmi K, Naveri H, HARKONEN M, Adlercreutz H . Plasma cortisol, androstenedione, testosterone and luteinizing hormone in running exercise of different intensities. Scand J Clin Lab Invest. 1980; 40(5):403-9. DOI: 10.3109/00365518009101862. View

12.

Bubb W, Howley E, Cox R . Effects of various levels of hypoxia on plasma catecholamines at rest and during exercise. Aviat Space Environ Med. 1983; 54(7):637-40. View

13.

Convertino V, Keil L, BERNAUER E, Greenleaf J . Plasma volume, osmolality, vasopressin, and renin activity during graded exercise in man. J Appl Physiol Respir Environ Exerc Physiol. 1981; 50(1):123-8. DOI: 10.1152/jappl.1981.50.1.123. View

14.

Jones N, Sutton J, Taylor R, Toews C . Effect of pH on cardiorespiratory and metabolic responses to exercise. J Appl Physiol Respir Environ Exerc Physiol. 1977; 43(6):959-64. DOI: 10.1152/jappl.1977.43.6.959. View

15.

Greenleaf J, BERNAUER E, Adams W, Juhos L . Fluid-electrolyte shifts and VO2max in man at simulated altitude (2,287 m). J Appl Physiol Respir Environ Exerc Physiol. 1978; 44(5):652-8. DOI: 10.1152/jappl.1978.44.5.652. View

16.

Stock M, Chapman C, Stirling J, Campbell I . Effects of exercise, altitude, and food on blood hormone and metabolite levels. J Appl Physiol Respir Environ Exerc Physiol. 1978; 45(3):350-4. DOI: 10.1152/jappl.1978.45.3.350. View

17.

Winder W, Hickson R, Hagberg J, Ehsani A, McLane J . Training-induced changes in hormonal and metabolic responses to submaximal exercise. J Appl Physiol Respir Environ Exerc Physiol. 1979; 46(4):766-71. DOI: 10.1152/jappl.1979.46.4.766. View

18.

Sutton J . Effect of acute hypoxia on the hormonal response to exercise. J Appl Physiol Respir Environ Exerc Physiol. 1977; 42(4):587-92. DOI: 10.1152/jappl.1977.42.4.587. View

19.

YOUNG A, Evans W, Cymerman A, Pandolf K, Knapik J, MAHER J . Sparing effect of chronic high-altitude exposure on muscle glycogen utilization. J Appl Physiol Respir Environ Exerc Physiol. 1982; 52(4):857-62. DOI: 10.1152/jappl.1982.52.4.857. View

20.

DESSYPRIS A, Kuoppasalmi K, Adlercreutz H . Plasma cortisol, testosterone, androstenedione and luteinizing hormone (LH) in a non-competitive marathon run. J Steroid Biochem. 1976; 7(1):33-7. DOI: 10.1016/0022-4731(76)90161-8. View