Altered White Matter Integrity in Patients with Retinal Vein Occlusion: A Diffusion Tensor Imaging and Tract-Based Spatial Statistics Study

Overview

Journal Dis Markers

Publisher Wiley

Specialty Biochemistry

Date 2022 Mar 7

PMID 35251379

Authors

Mou-Xin Zhang

Min-Jie Chen

Li-Ying Tang

Chen-Yu Yu

Yu-Ling Xu

San-Hua Xu

Ping Ying

Min Kang

Li-Juan Zhang

Yi Shao

Affiliations

Soon will be listed here.

Abstract

Background: To investigate microstructural alterations of white matter in retinal vein occlusion (RVO) patients by tract-based spatial statistics (TBSS) and diffusion tensor imaging (DTI). . DTI was performed on 14 RVO patients and 14 normal controls (HCs). We measured and recorded fractional anisotropy (FA) and radial diffusivity (RD) of white matter fibers and classified them through the receiver operating characteristic (ROC) curve and correlation analysis, respectively.

Results: The mean FA value of white matter in RVO patients is lower than the HCs, and the mean RD value in RVO patients increased, especially in the bilateral posterior thalamic, bilateral sagittal stratum, body of corpus callosum, cingulum, and fornix. The ROC curve of different brain regions showed high accuracy. Moreover, the mean FA and RD values were significantly correlated with visual and psychological disorders.

Conclusion: TBSS could be regarded as an important method to reveal the alterations of white matter in RVO patients, indicating the underlying neurological mechanism of the RVO.

Citing Articles

Altered synchronous neural activities in retinal vein occlusion patients: A resting-state fMRI study.

Xiao Y, Gan F, Liu H, Zhong Y Front Hum Neurosci. 2022; 16:961972.

PMID: 36188177 PMC: 9524247. DOI: 10.3389/fnhum.2022.961972.

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