Delayed-onset Organizing Pneumonia Emerging After Recovery from Coronavirus Disease 2019: A Report of Three Cases Diagnosed Using Transbronchial Cryobiopsy and a Review of the Literature

Overview

Journal Intern Med

Specialty General Medicine

Date 2022 Mar 7

PMID 35249922

Authors

Sho Nakakubo

Keisuke Kamada

Yu Yamashita

Junichi Nakamura

Munehiro Matsumoto

Hiroshi Horii

Kazuki Sato

Daisuke Morinaga

Masaru Suzuki

Nanase Okazaki

Emi Takakuwa

Yoshihiro Matsuno

Satoshi Konno

Affiliations

Soon will be listed here.

Abstract

We present three cases with an atypical clinical course of organizing pneumonia (OP) secondary to coronavirus disease 2019 (COVID-19). Three patients were discharged with satisfactory improvement after standard steroid therapy for COVID-19. Shortly after the completion of treatment, the patients experienced a flare-up of symptoms. Imaging results showed new lesions in the lungs. Transbronchial lung cryobiopsy showed histological findings consistent with OP in all cases. Steroids were administered, and a good therapeutic response was observed. This report is the first to describe pathologically confirmed OP that developed after recovery from COVID-19. Careful follow-up is advisable for patients who have recovered from COVID-19.

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