Toxicity of Organic Acids for Repair-deficient Strains of Escherichia Coli

Overview

Journal Appl Environ Microbiol

Specialties Environmental Health
Microbiology

Date 1986 Jun 1

PMID 3524457

Citations 6

Authors

R P Sinha

Affiliations

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Abstract

The wild-type strain and four DNA repair-deficient strains (uvrA6, uvrB5, recA56, and polA1) of Escherichia coli K-12 were treated with acetic acid, lactic acid, and p-aminobenzoic acid at pH 3.5 during their stationary phase of growth. All three acids were highly toxic to the polymerase-deficient strain. The greater sensitivity of the strain carrying the polA1 gene than its isogenic pol+ derivatives suggested that damage caused by acidity requires polA+ gene products for repair.

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