Human Endometrial Organoids: Recent Research Progress and Potential Applications

Overview

Journal Front Cell Dev Biol

Specialty Cell Biology

Date 2022 Mar 4

PMID 35242764

Authors

Liqun Lou

Shuangbo Kong

Yunyan Sun

Zhenbo Zhang

Haibin Wang

Affiliations

Soon will be listed here.

Abstract

Since traditional two-dimensional (2D) cell culture cannot meet the demand of simulating physiological conditions , three-dimensional (3D) culture systems have been developed. To date, most of these systems have been applied for the culture of gastrointestinal and neural tissue. As for the female reproductive system, the culture of endometrial and oviductal tissues in Matrigel has also been performed, but there are still some problems that remain unsolved. This review highlights recent progress regarding endometrial organoids, focusing on the signal for organoid derivation and maintenance, the coculture of the epithelium and stroma, the drug screening using organoids from cancer patients, and provides a potential guideline for genome editing in endometrial organoids.

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