Organoid Technologies for the Study of Intestinal Microbiota-host Interactions

Overview

Journal Trends Mol Med

Specialties General Medicine
Molecular Biology

Date 2022 Mar 2

PMID 35232671

Authors

Valentina Bozzetti

Stefania Senger

Affiliations

Soon will be listed here.

Abstract

Postbiotics have recently emerged as critical effectors of the activity of probiotics and, because of their safety profile, they are considered potential therapeutics for the treatment of fragile patients. Here, we present recent studies on probiotics and postbiotics in the context of novel discovery tools, such as organoids and organoid-based platforms, and nontransformed preclinical models, that can be generated from intestinal stem cells. The implementation of organoid-related techniques is the next gold standard for unraveling the effect of microbial communities on homeostasis, inflammation, idiopathic diseases, and cancer in the gut. We also summarize recent studies on biotics in organoid-based models and offer our perspective on future directions.

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