Determination of Age- and Sex-Specific 99th Percentile Upper Reference Limits for High-Sensitivity Cardiac Troponin I in Healthy Chinese Adults

Overview

Journal Cardiology

Specialty Cardiology & Vascular Diseases

Date 2022 Feb 27

PMID 35220311

Authors

Bing He

Kaijin Wang

Panyang Xu

Qi Zhou

Jiancheng Xu

Affiliations

Soon will be listed here.

Abstract

Introduction: Age- and sex-specific reference intervals (RIs) for high-sensitivity cardiac troponin I (hs-cTnI) are not available in China. The objective of the present research was to determine the assay-specific 99th percentile upper reference limits (URLs) for hs-cTnI in healthy Chinese adults.

Methods: Apparently healthy individuals were first screened with a questionnaire. The reference population was selected according to the International Federation of Clinical Chemistry (IFCC) criteria using surrogate biomarker for diabetes, myocardial dysfunction, and renal dysfunction. The serum concentration of hs-cTnI was measured using the automatized VITROS 5600 Immunodiagnostic system (Ortho Clinical Diagnostics, Raritan, NJ, USA).

Results: A total of 2,183 healthy individuals (1,051 men and 1,132 women aged from 20 to 95 years) were enrolled in the study. The serum overall 99th percentile URLs of hs-cTnI were 11.1 ng/L (12.5 ng/L in men, 9.6 ng/L in women). In both men and women, the 99th percentile URLs were significantly higher in individuals ≥55 years old than those in the <55 years old, especially in women. Moreover, 78.8% of males and 70.1% of females presented with hs-cTnI concentrations above the limit of detection of 0.43 ng/L.

Conclusion: The hs-cTnI-VITROS assay coincided with the performance standard of the IFCC for high-sensitivity cTnI assays. The 99th percentile URLs for hs-cTnI in healthy Chinese adults were different from the manufacturer declared and appeared heterogeneous, potentially susceptible to factors such as age and sex.

Citing Articles

Specific reference interval for high-sensitivity cardiac troponin I among healthy children in Wuhan, China.

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Optimizing the Clinical Use of High-Sensitivity Troponin Assays: A Review.

Tiwari D, Aw T Diagnostics (Basel). 2024; 14(1).

PMID: 38201396 PMC: 10795745. DOI: 10.3390/diagnostics14010087.

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