Functionalization and Antibacterial Applications of Cellulose-Based Composite Hydrogels

Overview

Journal Polymers (Basel)

Publisher MDPI

Date 2022 Feb 26

PMID 35215680

Authors

Yunhui Bao

Jian He

Ke Song

Jie Guo

Xianwu Zhou

Shima Liu

Affiliations

Soon will be listed here.

Abstract

Pathogens, especially drug-resistant pathogens caused by the abuse of antibiotics, have become a major threat to human health and public health safety. The exploitation and application of new antibacterial agents is extremely urgent. As a natural biopolymer, cellulose has recently attracted much attention due to its excellent hydrophilicity, economy, biocompatibility, and biodegradability. In particular, the preparation of cellulose-based hydrogels with excellent structure and properties from cellulose and its derivatives has received increasing attention thanks to the existence of abundant hydrophilic functional groups (such as hydroxyl, carboxy, and aldehyde groups) within cellulose and its derivatives. The cellulose-based hydrogels have broad application prospects in antibacterial-related biomedical fields. The latest advances of preparation and antibacterial application of cellulose-based hydrogels has been reviewed, with a focus on the antibacterial applications of composite hydrogels formed from cellulose and metal nanoparticles; metal oxide nanoparticles; antibiotics; polymers; and plant extracts. In addition, the antibacterial mechanism and antibacterial characteristics of different cellulose-based antibacterial hydrogels were also summarized. Furthermore, the prospects and challenges of cellulose-based antibacterial hydrogels in biomedical applications were also discussed.

Citing Articles

Targeting Acne: Development of Monensin-Loaded Nanostructured Lipid Carriers.

Abid F, Kim S, Savaliya B, Cesari L, Amirmostofian M, Abdella S Int J Nanomedicine. 2025; 20:2181-2204.

PMID: 39990290 PMC: 11847435. DOI: 10.2147/IJN.S497108.

An Overview of Potential Applications of Environmentally Friendly Hybrid Polymeric Materials.

Darie-Nita R, Frackowiak S Polymers (Basel). 2025; 17(2).

PMID: 39861324 PMC: 11768154. DOI: 10.3390/polym17020252.

Cationized Cellulose Materials: Enhancing Surface Adsorption Properties Towards Synthetic and Natural Dyes.

Negi A Polymers (Basel). 2025; 17(1.

PMID: 39795439 PMC: 11722886. DOI: 10.3390/polym17010036.

Physical stimuli-responsive polymeric patches for healthcare.

Cheng Y, Lu Y Bioact Mater. 2024; 43:342-375.

PMID: 39399837 PMC: 11470481. DOI: 10.1016/j.bioactmat.2024.08.025.

Antimicrobial Hydroxyethyl-Cellulose-Based Composite Films with Zinc Oxide and Mesoporous Silica Loaded with Cinnamon Essential Oil.

Motelica L, Ficai D, Petrisor G, Oprea O, Trusca R, Ficai A Pharmaceutics. 2024; 16(9).

PMID: 39339261 PMC: 11435203. DOI: 10.3390/pharmaceutics16091225.

References

Patwa R, Zandraa O, Capakova Z, Saha N, Saha P . Effect of Iron-Oxide Nanoparticles Impregnated Bacterial Cellulose on Overall Properties of Alginate/Casein Hydrogels: Potential Injectable Biomaterial for Wound Healing Applications. Polymers (Basel). 2020; 12(11). PMC: 7696874. DOI: 10.3390/polym12112690. View

Vinatier C, Gauthier O, Fatimi A, Merceron C, Masson M, Moreau A . An injectable cellulose-based hydrogel for the transfer of autologous nasal chondrocytes in articular cartilage defects. Biotechnol Bioeng. 2008; 102(4):1259-67. DOI: 10.1002/bit.22137. View

Park J, Kuang J, Lim Y, Gwon H, Nho Y . Characterization of silver nanoparticle in the carboxymethyl cellulose hydrogel prepared by a gamma ray irradiation. J Nanosci Nanotechnol. 2012; 12(1):743-7. DOI: 10.1166/jnn.2012.5366. View

Kenawy E, Worley S, Broughton R . The chemistry and applications of antimicrobial polymers: a state-of-the-art review. Biomacromolecules. 2007; 8(5):1359-84. DOI: 10.1021/bm061150q. View

Mokhena T, Luyt A . Electrospun alginate nanofibres impregnated with silver nanoparticles: Preparation, morphology and antibacterial properties. Carbohydr Polym. 2017; 165:304-312. DOI: 10.1016/j.carbpol.2017.02.068. View

Jernigan J, Hatfield K, Wolford H, Nelson R, Olubajo B, Reddy S . Multidrug-Resistant Bacterial Infections in U.S. Hospitalized Patients, 2012-2017. N Engl J Med. 2020; 382(14):1309-1319. PMC: 10961699. DOI: 10.1056/NEJMoa1914433. View

Liu K, Du H, Zheng T, Liu H, Zhang M, Zhang R . Recent advances in cellulose and its derivatives for oilfield applications. Carbohydr Polym. 2021; 259:117740. DOI: 10.1016/j.carbpol.2021.117740. View

Gao W, Chen Y, Zhang Y, Zhang Q, Zhang L . Nanoparticle-based local antimicrobial drug delivery. Adv Drug Deliv Rev. 2017; 127:46-57. PMC: 5860926. DOI: 10.1016/j.addr.2017.09.015. View

Umoren S, Eduok U . Application of carbohydrate polymers as corrosion inhibitors for metal substrates in different media: A review. Carbohydr Polym. 2016; 140:314-41. DOI: 10.1016/j.carbpol.2015.12.038. View

10.

Rasool A, Ata S, Islam A . Stimuli responsive biopolymer (chitosan) based blend hydrogels for wound healing application. Carbohydr Polym. 2018; 203:423-429. DOI: 10.1016/j.carbpol.2018.09.083. View

11.

Bampidis V, Azimonti G, Bastos M, Christensen H, Dusemund B, Kos Durjava M . Safety and efficacy of hydroxypropyl methyl cellulose for all animal species. EFSA J. 2020; 18(7):e06214. PMC: 7395937. DOI: 10.2903/j.efsa.2020.6214. View

12.

Bajpai S, Pathak V, Soni B . Minocycline-loaded cellulose nano whiskers/poly(sodium acrylate) composite hydrogel films as wound dressing. Int J Biol Macromol. 2015; 79:76-85. DOI: 10.1016/j.ijbiomac.2015.04.060. View

13.

Tavakolian M, Munguia-Lopez J, Valiei A, Islam M, Kinsella J, Tufenkji N . Highly Absorbent Antibacterial and Biofilm-Disrupting Hydrogels from Cellulose for Wound Dressing Applications. ACS Appl Mater Interfaces. 2020; 12(36):39991-40001. DOI: 10.1021/acsami.0c08784. View

14.

Wang Z, Fan X, He M, Chen Z, Wang Y, Ye Q . Construction of cellulose-phosphor hybrid hydrogels and their application for bioimaging. J Mater Chem B. 2020; 2(43):7559-7566. DOI: 10.1039/c4tb01240b. View

15.

George D, Maheswari P, Sheriffa Begum K, Arthanareeswaran G . Biomass-Derived Dialdehyde Cellulose Cross-linked Chitosan-Based Nanocomposite Hydrogel with Phytosynthesized Zinc Oxide Nanoparticles for Enhanced Curcumin Delivery and Bioactivity. J Agric Food Chem. 2019; 67(39):10880-10890. DOI: 10.1021/acs.jafc.9b01933. View

16.

Youssef A, Hasanin M, El-Aziz M, Turky G . Conducting chitosan/hydroxylethyl cellulose/polyaniline bionanocomposites hydrogel based on graphene oxide doped with Ag-NPs. Int J Biol Macromol. 2020; 167:1435-1444. DOI: 10.1016/j.ijbiomac.2020.11.097. View

17.

Benltoufa S, Miled W, Trad M, Slama R, Fayala F . Chitosan hydrogel-coated cellulosic fabric for medical end-use: Antibacterial properties, basic mechanical and comfort properties. Carbohydr Polym. 2019; 227:115352. DOI: 10.1016/j.carbpol.2019.115352. View

18.

Hrenovic J, Milenkovic J, Daneu N, Matonickin Kepcija R, Rajic N . Antimicrobial activity of metal oxide nanoparticles supported onto natural clinoptilolite. Chemosphere. 2012; 88(9):1103-7. DOI: 10.1016/j.chemosphere.2012.05.023. View

19.

Khamrai M, Lal Banerjee S, Paul S, Samanta S, Kundu P . Curcumin entrapped gelatin/ionically modified bacterial cellulose based self-healable hydrogel film: An eco-friendly sustainable synthesis method of wound healing patch. Int J Biol Macromol. 2018; 122:940-953. DOI: 10.1016/j.ijbiomac.2018.10.196. View

20.

Tong R, Chen G, Pan D, Qi H, Li R, Tian J . Highly Stretchable and Compressible Cellulose Ionic Hydrogels for Flexible Strain Sensors. Biomacromolecules. 2019; 20(5):2096-2104. DOI: 10.1021/acs.biomac.9b00322. View