Potential Roles and Key Mechanisms of Hawthorn Extract Against Various Liver Diseases

Overview

Journal Nutrients

Date 2022 Feb 26

PMID 35215517

Authors

Eujin Kim

Eungyeong Jang

Jang-Hoon Lee

Affiliations

Soon will be listed here.

Abstract

The genus (hawthorn), a flowering shrub or tree, is a member of the Rosaceae family and consists of approximately 280 species that have been primarily cultivated in East Asia, North America, and Europe. Consumption of hawthorn preparations has been chiefly associated with pharmacological benefits for cardiovascular diseases, including congestive heart failure and angina pectoris. Treatment with hawthorn extracts can be related to improvements in the complex pathogenesis of various hepatic and cardiovascular disorders. In this regard, the present review described that the presence of hawthorn extracts ameliorated hepatic injury, lipid accumulation, inflammation, fibrosis, and cancer in an abundance of experimental models. Hawthorn extracts might have these promising activities, largely by enhancing the hepatic antioxidant system. In addition, several mechanisms, including AMP-activated protein kinase (AMPK) signaling and apoptosis, are responsible for the role of hawthorn extracts in repairing the dysfunction of injured hepatocytes. Specifically, hawthorn possesses a wide range of biological actions relevant to the treatment of toxic hepatitis, alcoholic liver disease, non-alcoholic fatty liver disease, and hepatocellular carcinoma. Accordingly, hawthorn extracts can be developed as a major source of therapeutic agents for liver diseases.

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References

Manukyan A, Lumlerdkij N, Heinrich M . Caucasian endemic medicinal and nutraceutical plants: in-vitro antioxidant and cytotoxic activities and bioactive compounds. J Pharm Pharmacol. 2019; 71(7):1152-1161. DOI: 10.1111/jphp.13093. View

Lopez-Lazaro M . Flavonoids as anticancer agents: structure-activity relationship study. Curr Med Chem Anticancer Agents. 2003; 2(6):691-714. DOI: 10.2174/1568011023353714. View

Tapper E, Parikh N . Mortality due to cirrhosis and liver cancer in the United States, 1999-2016: observational study. BMJ. 2018; 362:k2817. PMC: 6050518. DOI: 10.1136/bmj.k2817. View

Kilicarslan A, Kahraman A, Akkiz H, Menziletoglu S, Fingas C, Gerken G . Apoptosis in selected liver diseases. Turk J Gastroenterol. 2009; 20(3):171-9. DOI: 10.4318/tjg.2009.0003. View

Nunes R, Pasko P, Tyszka-Czochara M, Szewczyk A, Szlosarczyk M, Carvalho I . Antibacterial, antioxidant and anti-proliferative properties and zinc content of five south Portugal herbs. Pharm Biol. 2016; 55(1):114-123. PMC: 7011791. DOI: 10.1080/13880209.2016.1230636. View

Caligiani A, Malavasi G, Palla G, Marseglia A, Tognolini M, Bruni R . A simple GC-MS method for the screening of betulinic, corosolic, maslinic, oleanolic and ursolic acid contents in commercial botanicals used as food supplement ingredients. Food Chem. 2012; 136(2):735-41. DOI: 10.1016/j.foodchem.2012.08.011. View

Li S, Tan H, Wang N, Zhang Z, Lao L, Wong C . The Role of Oxidative Stress and Antioxidants in Liver Diseases. Int J Mol Sci. 2015; 16(11):26087-124. PMC: 4661801. DOI: 10.3390/ijms161125942. View

Keskin N, Mammadov R, Ili P . The effects of Crataegus aronia var. dentata Browicz extract on biochemical indices and apoptosis in partially hepatectomized liver in rats. Bosn J Basic Med Sci. 2012; 12(3):177-81. PMC: 4362427. DOI: 10.17305/bjbms.2012.2472. View

Abu-Gharbieh E, Shehab N . Therapeutic potentials of Crataegus azarolus var. eu- azarolus Maire leaves and its isolated compounds. BMC Complement Altern Med. 2017; 17(1):218. PMC: 5395866. DOI: 10.1186/s12906-017-1729-9. View

10.

Zhu R, Sun Y, Hou Y, Fan J, Chen G, Li T . Pectin penta-oligogalacturonide reduces cholesterol accumulation by promoting bile acid biosynthesis and excretion in high-cholesterol-fed mice. Chem Biol Interact. 2017; 272:153-159. DOI: 10.1016/j.cbi.2017.05.018. View

11.

Jouad H, Lemhadri A, Maghrani M, Burcelin R, Eddouks M . Hawthorn evokes a potent anti-hyperglycemic capacity in streptozotocin-induced diabetic rats. J Herb Pharmacother. 2004; 3(2):19-29. View

12.

Inamdar S, Joshi A, Malik S, Boppana R, Ghaskadbi S . Vitexin alleviates non-alcoholic fatty liver disease by activating AMPK in high fat diet fed mice. Biochem Biophys Res Commun. 2019; 519(1):106-112. DOI: 10.1016/j.bbrc.2019.08.139. View

13.

Tahmasebi M, Sadeghi H, Nazem H, Kokhdan E, Omidifar N . Hepatoprotective effects of leaf extract on carbon tetrachloride-induced hepatotoxicity in rats. J Educ Health Promot. 2019; 7:147. PMC: 6282695. DOI: 10.4103/jehp.jehp_48_17. View

14.

Bernal W, Wendon J . Acute liver failure. N Engl J Med. 2013; 369(26):2525-34. DOI: 10.1056/NEJMra1208937. View

15.

Huang X, Zhou C, Li L, Peng Y, Lou L, Liu S . Cytotoxic and antioxidant dihydrobenzofuran neolignans from the seeds of Crataegus pinnatifida. Fitoterapia. 2013; 91:217-223. DOI: 10.1016/j.fitote.2013.09.011. View

16.

Musso G, Gambino R, Cassader M . Recent insights into hepatic lipid metabolism in non-alcoholic fatty liver disease (NAFLD). Prog Lipid Res. 2008; 48(1):1-26. DOI: 10.1016/j.plipres.2008.08.001. View

17.

Daniele C, Mazzanti G, Pittler M, Ernst E . Adverse-event profile of Crataegus spp.: a systematic review. Drug Saf. 2006; 29(6):523-35. DOI: 10.2165/00002018-200629060-00005. View

18.

Li C, Chen Y, Yuan X, He L, Li X, Huang S . Vitexin ameliorates chronic stress plub high fat diet-induced nonalcoholic fatty liver disease by inhibiting inflammation. Eur J Pharmacol. 2020; 882:173264. DOI: 10.1016/j.ejphar.2020.173264. View

19.

Huang X, Zhou C, Li L, Li F, Lou L, Li D . The cytotoxicity of 8-O-4' neolignans from the seeds of Crataegus pinnatifida. Bioorg Med Chem Lett. 2013; 23(20):5599-604. DOI: 10.1016/j.bmcl.2013.08.045. View

20.

Yoo J, Liu Y, Kim H . Hawthorn Fruit Extract Elevates Expression of Nrf2/HO-1 and Improves Lipid Profiles in Ovariectomized Rats. Nutrients. 2016; 8(5). PMC: 4882696. DOI: 10.3390/nu8050283. View