Ocular Complications Following Vaccination for COVID-19: A One-Year Retrospective

Overview

Journal Vaccines (Basel)

Date 2022 Feb 26

PMID 35214800

Authors

Abid A Haseeb

Omar Solyman

Mokhtar M Abushanab

Ahmed S Abo Obaia

Abdelrahman M Elhusseiny

Affiliations

Soon will be listed here.

Abstract

Vaccination efforts as a mitigation strategy in the corona virus disease 2019 (COVID-19) pandemic are fully underway. A vital component of understanding the optimal clinical use of these vaccines is a thorough investigation of adverse events following vaccination. To date, some limited reports and reviews have discussed ocular adverse events following COVID-19 vaccination, but a systematic review detailing these reports with manifestations and clinical courses as well as proposed mechanisms has yet to be published. This comprehensive review one-year into vaccination efforts against COVID-19 is meant to furnish sound understanding for ophthalmologists and primary care physicians based on the existing body of clinical data. We discuss manifestations categorized into one of the following: eyelid, orbit, uveitis, retina, vascular, neuro-ophthalmology, ocular motility disorders, and other.

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References

Rao N, Gupta A, Dustin L, Chee S, Okada A, Khairallah M . Frequency of distinguishing clinical features in Vogt-Koyanagi-Harada disease. Ophthalmology. 2009; 117(3):591-9, 599.e1. PMC: 2830365. DOI: 10.1016/j.ophtha.2009.08.030. View

Book B, Schmidt B, Foerster A . Bilateral Acute Macular Neuroretinopathy After Vaccination Against SARS-CoV-2. JAMA Ophthalmol. 2021; 139(7):e212471. DOI: 10.1001/jamaophthalmol.2021.2471. View

Austria Q, Lelli G, Segal K, Godfrey K . Transient Eyelid Edema Following COVID-19 Vaccination. Ophthalmic Plast Reconstr Surg. 2021; 37(5):501-502. PMC: 8425512. DOI: 10.1097/IOP.0000000000002042. View

Goyal M, Murthy S, Annum S . Bilateral Multifocal Choroiditis following COVID-19 Vaccination. Ocul Immunol Inflamm. 2021; 29(4):753-757. DOI: 10.1080/09273948.2021.1957123. View

Vignapiano R, Vicchio L, Favuzza E, Cennamo M, Mencucci R . Corneal Graft Rejection after Yellow Fever Vaccine: A Case Report. Ocul Immunol Inflamm. 2021; 30(5):1207-1210. DOI: 10.1080/09273948.2020.1870146. View

Mishra S, Mahendradas P, Kawali A, Sanjay S, Shetty R . Reactivation of varicella zoster infection presenting as acute retinal necrosis post COVID 19 vaccination in an Asian Indian male. Eur J Ophthalmol. 2021; 33(1):NP32-NP36. DOI: 10.1177/11206721211046485. View

Premkumar M, Bhujade H, Karki T, Chaluvashetty S, Kaur H, Duseja A . New Portal Vein Thrombosis in Cirrhosis - is the Thrombophilia Exacerbated due to Vaccine or COVID-19?. J Clin Exp Hepatol. 2021; 12(3):1025-1028. PMC: 8574119. DOI: 10.1016/j.jceh.2021.10.149. View

Chen S, Hodge C . Comment on: 'Acute macular neuroretinopathy following COVID-19 vaccination'. Eye (Lond). 2021; 36(7):1513-1514. PMC: 8477725. DOI: 10.1038/s41433-021-01781-x. View

Wertheim M, Keel M, Cook S, Tole D . Corneal transplant rejection following influenza vaccination. Br J Ophthalmol. 2006; 90(7):925. PMC: 1857166. DOI: 10.1136/bjo.2006.093187. View

10.

Herbort Jr C, Papasavvas I . Effect of SARS-CoV-2 mRNA vaccination on ocular herpes simplex and varicella-zoster virus reactivation: should preventive antiviral treatment be given in known herpes patients. J Ophthalmic Inflamm Infect. 2021; 11(1):33. PMC: 8446741. DOI: 10.1186/s12348-021-00262-2. View

11.

Khan T, Sidhu N, Khan L, Sen S, Hussain N, Tandon R . Bilateral Immune-Mediated Keratolysis After Immunization With SARS-CoV-2 Recombinant Viral Vector Vaccine. Cornea. 2021; 40(12):1629-1632. DOI: 10.1097/ICO.0000000000002844. View

12.

Endo B, Bahamon S, Martinez-Pulgarin D . Central retinal vein occlusion after mRNA SARS-CoV-2 vaccination: A case report. Indian J Ophthalmol. 2021; 69(10):2865-2866. PMC: 8597478. DOI: 10.4103/ijo.IJO_1477_21. View

13.

Mazzatenta C, Piccolo V, Pace G, Romano I, Argenziano G, Bassi A . Purpuric lesions on the eyelids developed after BNT162b2 mRNA COVID-19 vaccine: another piece of SARS-CoV-2 skin puzzle?. J Eur Acad Dermatol Venereol. 2021; 35(9):e543-e545. PMC: 8242437. DOI: 10.1111/jdv.17340. View

14.

Fawzi A, Pappuru R, Sarraf D, Le P, McCannel C, Sobrin L . Acute macular neuroretinopathy: long-term insights revealed by multimodal imaging. Retina. 2012; 32(8):1500-13. DOI: 10.1097/IAE.0b013e318263d0c3. View

15.

Barnaba V . Viruses, hidden self-epitopes and autoimmunity. Immunol Rev. 1996; 152:47-66. DOI: 10.1111/j.1600-065x.1996.tb00910.x. View

16.

Moulis G, Sailler L, Sommet A, Lapeyre-Mestre M, Adoue D . Prevalence of pneumococcal vaccination in adult immune thrombocytopenia patients exposed to rituximab or to splenectomy. Eur J Haematol. 2013; 90(5):438-9. DOI: 10.1111/ejh.12091. View

17.

Druke D, Pleyer U, Hoerauf H, Feltgen N, Bemme S . Acute macular neuroretinopathy (AMN) following COVID-19 vaccination. Am J Ophthalmol Case Rep. 2021; 24:101207. PMC: 8457905. DOI: 10.1016/j.ajoc.2021.101207. View

18.

Wasser L, Roditi E, Zadok D, Berkowitz L, Weill Y . Keratoplasty Rejection After the BNT162b2 messenger RNA Vaccine. Cornea. 2021; 40(8):1070-1072. PMC: 8244807. DOI: 10.1097/ICO.0000000000002761. View

19.

Ishay Y, Kenig A, Tsemach-Toren T, Amer R, Rubin L, Hershkovitz Y . Autoimmune phenomena following SARS-CoV-2 vaccination. Int Immunopharmacol. 2021; 99:107970. PMC: 8270741. DOI: 10.1016/j.intimp.2021.107970. View

20.

Nahill S, Welsh R . High frequency of cross-reactive cytotoxic T lymphocytes elicited during the virus-induced polyclonal cytotoxic T lymphocyte response. J Exp Med. 1993; 177(2):317-27. PMC: 2190893. DOI: 10.1084/jem.177.2.317. View