How Aging of the Global Population is Changing Oncology

Overview

Journal Ecancermedicalscience

Specialty Oncology

Date 2022 Feb 25

PMID 35211208

Authors

Yan Fei Gu

Frank P Lin

Richard J Epstein

Affiliations

Soon will be listed here.

Abstract

Population aging is causing a demographic redistribution with implications for the future of healthcare. How will this affect oncology? First, there will be an overall rise in cancer affecting older adults, even though age-specific cancer incidences continue to fall due to better prevention. Second, there will be a wider spectrum of health functionality in this expanding cohort of older adults, with differences between "physiologically older" and "physiologically younger" patients becoming more important for optimal treatment selection. Third, greater teamwork with supportive care, geriatric, mental health and rehabilitation experts will come to enrich oncologic decision-making by making it less formulaic than it is at present. Success in this transition to a more nuanced professional mindset will depend in part on the development of user-friendly computational tools that can integrate a complex mix of quantitative and qualitative inputs from evidence-based medicine, functional and cognitive assessments, and the personal priorities of older adults.

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References

Mighton C, Carlsson L, Clausen M, Casalino S, Shickh S, McCuaig L . Development of patient "profiles" to tailor counseling for incidental genomic sequencing results. Eur J Hum Genet. 2019; 27(7):1008-1017. PMC: 6777527. DOI: 10.1038/s41431-019-0352-2. View

Rzeniewicz K, Larkin J, Menzies A, Turajlic S . Immunotherapy use outside clinical trial populations: never say never?. Ann Oncol. 2021; 32(7):866-880. PMC: 9246438. DOI: 10.1016/j.annonc.2021.03.199. View

van Baalen S, Boon M . An epistemological shift: from evidence-based medicine to epistemological responsibility. J Eval Clin Pract. 2014; 21(3):433-9. DOI: 10.1111/jep.12282. View

Soto-Perez-de-Celis E, Li D, Yuan Y, Lau Y, Hurria A . Functional versus chronological age: geriatric assessments to guide decision making in older patients with cancer. Lancet Oncol. 2018; 19(6):e305-e316. DOI: 10.1016/S1470-2045(18)30348-6. View

Pozuelo-Carrascosa D, Alvarez-Bueno C, Cavero-Redondo I, Morais S, Lee I, Martinez-Vizcaino V . Cardiorespiratory fitness and site-specific risk of cancer in men: A systematic review and meta-analysis. Eur J Cancer. 2019; 113:58-68. DOI: 10.1016/j.ejca.2019.03.008. View

Extermann M, Brain E, Canin B, Cherian M, Cheung K, de Glas N . Priorities for the global advancement of care for older adults with cancer: an update of the International Society of Geriatric Oncology Priorities Initiative. Lancet Oncol. 2021; 22(1):e29-e36. DOI: 10.1016/S1470-2045(20)30473-3. View

Haque W, Alvarenga M, Hsiehchen D . Nonresearch Pharmaceutical Industry Payments to Oncology Physician Editors. Oncologist. 2020; 25(6):e986-e989. PMC: 7288645. DOI: 10.1634/theoncologist.2019-0828. View

Nipp R, Greer J, El-Jawahri A, Moran S, Traeger L, Jacobs J . Coping and Prognostic Awareness in Patients With Advanced Cancer. J Clin Oncol. 2017; 35(22):2551-2557. PMC: 5536163. DOI: 10.1200/JCO.2016.71.3404. View

Seals D, Justice J, LaRocca T . Physiological geroscience: targeting function to increase healthspan and achieve optimal longevity. J Physiol. 2015; 594(8):2001-24. PMC: 4933122. DOI: 10.1113/jphysiol.2014.282665. View

10.

Selman C, Swindell W . Putting a strain on diversity. EMBO J. 2018; 37(22). PMC: 6236330. DOI: 10.15252/embj.2018100862. View

11.

Brogan A, DeMuro C, Barrett A, DAlessio D, Bal V, Hogue S . Payer Perspectives on Patient-Reported Outcomes in Health Care Decision Making: Oncology Examples. J Manag Care Spec Pharm. 2017; 23(2):125-134. PMC: 10397630. DOI: 10.18553/jmcp.2017.23.2.125. View

12.

Winckworth-Prejsnar K, McCanney J, Schatz A, Smedley W, Platanias L, Benitez C . Policy Challenges and Opportunities to Address Changing Paradigms in Cancer Care Delivery. J Natl Compr Canc Netw. 2019; 17(5):424-431. DOI: 10.6004/jnccn.2019.7299. View

13.

ODonovan A, Leech M . Personalised treatment for older adults with cancer: The role of frailty assessment. Tech Innov Patient Support Radiat Oncol. 2020; 16:30-38. PMC: 7568178. DOI: 10.1016/j.tipsro.2020.09.001. View

14.

Pamoukdjian F, Liuu E, Caillet P, Herbaud S, Gisselbrecht M, Poisson J . How to Optimize Cancer Treatment in Older Patients: An Overview of Available Geriatric Tools. Am J Clin Oncol. 2018; 42(2):109-116. DOI: 10.1097/COC.0000000000000488. View

15.

Overcash J, Ford N, Kress E, Ubbing C, Williams N . Comprehensive Geriatric Assessment as a Versatile Tool to Enhance the Care of the Older Person Diagnosed with Cancer. Geriatrics (Basel). 2019; 4(2). PMC: 6630523. DOI: 10.3390/geriatrics4020039. View

16.

Kim K, Kim O . Super Aging in South Korea Unstoppable but Mitigatable: A Sub-National Scale Population Projection for Best Policy Planning. Spat Demogr. 2021; 8(2):155-173. PMC: 8248505. DOI: 10.1007/s40980-020-00061-8. View

17.

Buchkowsky S, Jewesson P . Industry sponsorship and authorship of clinical trials over 20 years. Ann Pharmacother. 2004; 38(4):579-85. DOI: 10.1345/aph.1D267. View

18.

De Silva D, Ranasinghe W, Bandaragoda T, Adikari A, Mills N, Iddamalgoda L . Machine learning to support social media empowered patients in cancer care and cancer treatment decisions. PLoS One. 2018; 13(10):e0205855. PMC: 6193663. DOI: 10.1371/journal.pone.0205855. View

19.

Carmona J, Michan S . Biology of Healthy Aging and Longevity. Rev Invest Clin. 2016; 68(1):7-16. View

20.

Seltzer N . Beyond the Great Recession: Labor Market Polarization and Ongoing Fertility Decline in the United States. Demography. 2019; 56(4):1463-1493. PMC: 7197790. DOI: 10.1007/s13524-019-00790-6. View