Explore the Anti-Acne Mechanism of Licorice Flavonoids Based on Metabonomics and Microbiome

Overview

Journal Front Pharmacol

Date 2022 Feb 25

PMID 35211023

Authors

Shi-Fa Ruan

Yi Hu

Wen-Feng Wu

Qun-Qun Du

Zhu-Xian Wang

Ting-Ting Chen

Qun Shen

Li Liu

Cui-Ping Jiang

Hui Li

Yankui Yi

Chun-Yan Shen

Hong-Xia Zhu

Qiang Liu

Affiliations

Soon will be listed here.

Abstract

Acne vulgaris is one of the most common inflammatory dermatoses in dermatological practice and can affect any gender or ethnic group. Although in previous studies, we had found that licorice flavonoids (LCF) play an anti-acne role by inhibiting PI3K-Akt signaling pathways and mitochondrial activity, the mechanism of LCF regulating skin metabolism, serum metabolism and skin microbes is still unclear. Here, we performed a full spectrum analysis of metabolites in the skin and serum using UHPLC-Triple TOF-MS. The results showed that LCF could treat acne by regulating the metabolic balance of amino acids, lipids and fatty acids in serum and skin. Similarly, we performed Illumina Hiseq sequencing of DNA from the skin microbes using 16S ribosomal DNA identification techniques. The results showed that LCF could treat acne by regulating the skin microbes to interfere with acne and make the microecology close to the normal skin state of rats. In summary, this study confirmed the anti-acne mechanism of LCF, namely by regulating metabolic balance and microbial balance. Therefore, this discovery will provide theoretical guidance for the preparation development and clinical application of the drug.

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