Immunomodulatory Properties of Masticadienonic Acid and 3α-Hydroxy Masticadienoic Acid in Dendritic Cells

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2022 Feb 25

PMID 35209237

Authors

Gabriela Pinon-Zarate

Fernanda Reyes-Riquelme

Ma Beatriz Sanchez-Monroy

Monica Velasco-Torrez

Mariano Martinez-Vazquez

Christian Adrian Cardenas-Monroy

Beatriz Hernandez-Tellez

Katia Jarquin-Yanez

Miguel Angel Herrera-Enriquez

Andres Eliu Castell-Rodriguez

Affiliations

Soon will be listed here.

Abstract

Dendritic cells are antigen-presenting cells, which identify and process pathogens to subsequently activate specific T lymphocytes. To regulate the immune responses, DCs have to mature by the recognition of TLR ligands, TNFα or IFNγ. These ligands have been used as adjuvants to activate DCs in situ or in vitro, with toxic effects. It has been shown that some molecules affect the immune system, e.g., Masticadienonic acid (MDA) and 3α-hydroxy masticadienoic acid (3α-OH MDA) triterpenes naturally occurring in several medicinal plants, since they activate the nitric oxide synthase in macrophages and induce T lymphocyte proliferation. The DCs maturation induced by MDA or 3a-OH MDA was determined by incubating these cells with MDA or 3α-OH MDA, and their phenotype was afterwards analyzed. The results showed that only 3α-OH MDA was able to induce DCs maturation. When mice with melanoma were inoculated with DCs/3α-OH MDA, a decreased tumor growth rate was observed along with an extended cell death area within tumors compared to mice treated with DCs incubated with MDA. In conclusion, it is proposed that 3α-OH MDA may be an immunostimulant molecule. Conversely, it is proposed that MDA may be a molecule with anti-inflammatory properties.

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