The Predictive Role of Serum Levels of Soluble Cell Adhesion Molecules (sCAMs) in the Therapy of Advanced Breast Cancer-A Single-Centre Study

Overview

Journal Medicina (Kaunas)

Publisher MDPI

Specialty General Medicine

Date 2022 Feb 25

PMID 35208477

Authors

Weronika Bulska-Bedkowska

Paulina Czajka-Francuz

Sylwia Jurek-Cison

Aleksander J Owczarek

Tomasz Francuz

Jerzy Chudek

Affiliations

Soon will be listed here.

Abstract

Soluble cell adhesion molecules (sCAMs) play a significant role in the metastatic potential of breast cancer (BC). They might block lymphocytes and promote angiogenesis and migration of cancer cells. We assessed the usefulness of sCAMs in the prognosis and monitoring of the progression of advanced BC. We assessed soluble E-selectin, P-selectin, VCAM-1, ICAM-1, EpCAM, IL-6Ra, TNF-R1, and TNF-R2 in 39 women with aBC. Blood samples were obtained at the beginning of the treatment and after 2 months. The median progression-free survival (PFS) was 9 months, and overall survival (OS) was 27 months. The higher levels of sICAM-1 (HR = 2.60, = 0.06) and lower levels of sEpCAM (HR = 2.72, < 0.05) were associated with faster progression of aBC. High levels of sEpCAM through the follow-up period were significantly associated with a lower risk of progression (HR = 0.40, < 0.01). We found the independent predictive value of higher than median sICAM-1 levels for PFS (HR = 2.07, = 0.08) and of sVCAM-1 levels for OS (HR = 2.59, < 0.05). Our data support the predictive value of sICAM-1 and sVCAM-1 and suggest that they could become markers for tailoring new therapies in aBC. sEpCAM level could be used as an early indicator of response to the therapy.

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