Investigating the Role of Insight, Decision-Making and Mentalizing in Functional Outcome in Schizophrenia: A Cross-Sectional Study

Overview

Journal Behav Sci (Basel)

Date 2022 Feb 24

PMID 35200280

Authors

Paula Jhoana Escobedo-Aedo

Ana Forjan-Gonzalez

Adela Sanchez-Escribano Martinez

Veronica Gonzalez Ruiz-Ruano

Sergio Sanchez-Alonso

Laura Mata-Iturralde

Laura Munoz-Lorenzo

Enrique Baca-Garcia

Anthony S David

Javier-David Lopez-Morinigo

Affiliations

Soon will be listed here.

Abstract

Background: Recovery has become a priority in schizophrenia spectrum disorders (SSDs). This study aimed to investigate predictors of objective-general functioning and disability-and subjective-quality of life (QoL)-measures of functional outcomes in SSD.

Methods: Sample: = 77 SSD outpatients (age 18-64, IQ > 70) participating in a randomised controlled trial. Baseline data were used to build three multivariable linear regression models on: (i) general functioning-General Assessment of Functioning (GAF); (ii) disability-the World Health Organization Disability Assessment Schedule (WHODAS-2.0); and (iii) QoL-Satisfaction Life Domains Scale (SLDS).

Results: Young age and being employed (R change = 0.211; = 0.001), late adolescence premorbid adjustment (R change = 0.049; = 0.0050), negative symptoms and disorganization (R change = 0.087; = 0.025) and Theory of Mind (R change = 0.066, = 0.053) predicted general functioning. Previous suicidal behaviour (R change = 0.068; = 0.023) and negative and depressive symptoms (R change = 0.167; = 0.001) were linked with disability. Previous suicidal behaviour (R change = 0.070, = 0.026), depressive symptoms (R change = 0.157; < 0.001) and illness recognition (R change = 0.046, = 0.044) predicted QoL.

Conclusions: Negative, disorganization and depressive symptoms, older age, unemployment, poor premorbid adjustment, previous suicide attempts and illness awareness appear to underlie a poor global functional outcome in SSD. Achieving recovery in SSD appears to require both symptomatic remission (e.g., through antipsychotics) and measures to improve mastery and relieve low mood.

Citing Articles

Evaluation of the Relationship between Disability and Disease Severity, Cognitive Functions, and Insight in Patients with Schizophrenia.

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The Satisfaction with Life Domains Scale as an instrument for assessing quality - a psychometric evaluation.

Wciorka J, Jablonska M Postep Psychiatr Neurol. 2023; 32(3):115-127.

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