Appearance of Specific Antibody-bearing Cells in Human Bronchial Mucosa After Local Immunization with Bacterial Vaccine

Overview

Journal J Clin Microbiol

Specialty Microbiology

Date 1986 Jun 1

PMID 3519666

Citations 1

Authors

F Latil

D Vervloet

P Casanova

L Garbe

P Fuentes

N Wierzbicki

J CHARPIN

Affiliations

Soon will be listed here.

Abstract

The immune response to local in vivo inhalation of a lysed bacteria vaccine was assessed in surgical specimens of main-stem bronchi from patients who had undergone pneumectomy for cancer. The patient population included 22 subjects; 11 of these received the aerosol vaccine twice a day for 10 days prior to surgery, while the remaining 11 patients were used as controls and were not immunized. The submucous glands of immunized subjects showed significantly more cells than did those of the controls, i.e., 62 +/- 8 versus 37 +/- 7, respectively (P less than 0.05). The following five antigens were chosen for study by fluorescence assay: Streptococcus pneumoniae types II and III, Haemophilus influenzae, Streptococcus sp. strain D19, and Klebsiella pneumoniae. An immunization-dependent correlation was found between immunoglobulin A, immunoglobulin A-bearing cells, and specific antibody-bearing cells on the one hand and three of the five antigens (S. pneumoniae types II and III and Streptococcus sp. strain D19) on the other hand. This is the first time that a relationship has been established between bacterial immunization of the lower respiratory tract and local immunoglobulin production in humans.

Citing Articles

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Motamed H, Yari F, Javadirad E, Golmohammadi S, Alimoradi S, Naleini R Health Sci Rep. 2024; 7(9):e70061.

PMID: 39263537 PMC: 11387585. DOI: 10.1002/hsr2.70061.

References

Smith T, Buescher E, Top Jr F, Altemeier W, McCown J . Experimental respiratory infection with type 4 adenovirus vaccine in volunteers: clinical and immunological responses. J Infect Dis. 1970; 122(4):239-48. DOI: 10.1093/infdis/122.4.239. View

Waldman R, Henney C . Cell-mediated immunity and antibody responses in the respiratory tract after local and systemic immunization. J Exp Med. 1971; 134(2):482-94. PMC: 2139041. DOI: 10.1084/jem.134.2.482. View

Werner H . [Use of inhalation vaccination in chronic bronchitis in man and its immunologic effect]. Prax Pneumol. 1974; 28 Suppl:846-8. View

Reynolds H, Kazmierowski J, Newball H . Specificity of opsonic antibodies to enhance phagocytosis of Pseudomonas aeruginosa by human alveolar macrophages. J Clin Invest. 1975; 56(2):376-85. PMC: 436596. DOI: 10.1172/JCI108102. View

KALTREIDER H, Chan M . The class-specific immunoglobulin composition of fluids obtained from various levels of the canine respiratory tract. J Immunol. 1976; 116(2):423-9. View

KALTREIDER H . Expression of immune mechanisms in the lung. Am Rev Respir Dis. 1976; 113(3):347-79. DOI: 10.1164/arrd.1976.113.3.347. View

Nakashima I, Kojima T, Kato N . Cellular aspects of non-specific stimulation of antibody production by capsular polysaccharide of Klebsiella pneumoniae. Immunology. 1976; 30(2):229-40. PMC: 1444990. View

Soutar C . Distribution of plasma cells and other cells containing immunoglobulin in the respiratory tract of normal man and class of immunoglobulin contained therein. Thorax. 1976; 31(2):158-66. PMC: 470378. DOI: 10.1136/thx.31.2.158. View

Jakab G . Factors influencing the immune enhancement of intrapulmonary bactericidal mechanisms. Infect Immun. 1976; 14(2):389-98. PMC: 420896. DOI: 10.1128/iai.14.2.389-398.1976. View

10.

Ferron G, Kerrebijn K, Weber J . Properties of aerosols produced with three nebulizers. Am Rev Respir Dis. 1976; 114(5):899-908. DOI: 10.1164/arrd.1976.114.5.899. View

11.

Reynolds H, Fulmer J, Kazmierowski J, Roberts W, Frank M, Crystal R . Analysis of cellular and protein content of broncho-alveolar lavage fluid from patients with idiopathic pulmonary fibrosis and chronic hypersensitivity pneumonitis. J Clin Invest. 1977; 59(1):165-75. PMC: 333344. DOI: 10.1172/JCI108615. View

12.

Morrison D, Kline L . Activation of the classical and properdin pathways of complement by bacterial lipopolysaccharides (LPS). J Immunol. 1977; 118(1):362-8. View

13.

Hudson A, Kilburn K, Halprin G, McKenzie W . Granulocyte recruitment to airways exposed to endotoxin aerosols. Am Rev Respir Dis. 1977; 115(1):89-95. DOI: 10.1164/arrd.1977.115.1.89. View

14.

Austrian R, Douglas R, Schiffman G, Coetzee A, Koornhof H, HAYDEN-SMITH S . Prevention of pneumococcal pneumonia by vaccination. Trans Assoc Am Physicians. 1976; 89:184-94. View

15.

Green G, Jakab G, Low R, Davis G . Defense mechanisms of the respiratory membrane. Am Rev Respir Dis. 1977; 115(3):479-514. DOI: 10.1164/arrd.1977.115.3.479. View

16.

Hunninghake G, Fauci A . Immunolgic reactivity of the lung. V. Regulatory effects of antibody on the pulmonary immune response to locally administered antigen. J Immunol. 1977; 118(5):1728-33. View

17.

Soutar C . Distribution of plasma cells and other cells containing immunoglobulin in the respiratory tract in chronic bronchitis. Thorax. 1977; 32(4):387-96. PMC: 470636. DOI: 10.1136/thx.32.4.387. View

18.

McLeod E, Caldwell J, KALTREIDER H . Pulmonary immune responses of inbred mice. Appearance of antibody-forming cells in C57BL/6 mice after intrapulmonary or systemic immunization with sheep erythrocytes. Am Rev Respir Dis. 1978; 118(3):561-71. DOI: 10.1164/arrd.1978.118.3.561. View

19.

BRADLEY S . Cellular and molecular mechanisms of action of bacterial endotoxins. Annu Rev Microbiol. 1979; 33:67-94. DOI: 10.1146/annurev.mi.33.100179.000435. View

20.

TOMASI Jr T, Larson L, Challacombe S, McNabb P . Mucosal immunity: The origin and migration patterns of cells in the secretory system. J Allergy Clin Immunol. 1980; 65(1):12-9. DOI: 10.1016/0091-6749(80)90171-2. View