Protection of Mice Against Lethal Endotoxemia by a Lipid A Precursor

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 1986 Jun 1

PMID 3519466

Citations 29

Authors

R A Proctor

J A Will

K E Burhop

C R Raetz

Affiliations

Soon will be listed here.

Abstract

Lipid X, the major biosynthetic precursor of lipid A, has recently been described. Although lipid X is a mitogen and coagulates the Limulus amebocyte lysate, we found that it is not lethal for mice, even when given in large doses (2 X 10(6) micrograms/kg). Furthermore, lipid X was found to give partial protection against a 100% lethal dose of endotoxin, even if the lipid X was given as late as 6 h after endotoxin challenge.

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