Visible-Light Mediated Oxidative Fragmentation of Ethers and Acetals by Means of Fe(III) Catalysis

Overview

Journal Org Lett

Publisher American Chemical Society

Specialties Biochemistry
Chemistry

Date 2022 Feb 22

PMID 35192351

Authors

Rickard Lindroth

Alica Ondrejkova

Carl-Johan Wallentin

Affiliations

Soon will be listed here.

Abstract

A new method employing iron(III) acetylacetonate along with visible light is described to effect oxidative ring opening of cyclic ethers and acetals with unparalleled efficiency. The method allows for a photocatalytic radical chemistry approach to functionalize relatively inert cyclic ethers into useful synthetic intermediates. The methodology sheds further light on the use of underexplored iron complexes in visible-light photochemical contexts and illustrates that simple Fe(III) complexes can initiate redox processes from LMCT excited states.

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PMID: 37079887 PMC: 10161236. DOI: 10.1021/jacs.3c01000.

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