Time to Lost to Follow-up and Its Predictors Among Adult Patients Receiving Antiretroviral Therapy Retrospective Follow-up Study Amhara Northwest Ethiopia

Overview

Journal Sci Rep

Specialty Science

Date 2022 Feb 22

PMID 35190629

Authors

Animut Takele Telayneh

Mulugeta Tesfa

Wubetu Woyraw

Habtamu Temesgen

Nakachew Mekonnen Alamirew

Dessalegn Haile

Yilkal Tafere

Pammla Petrucka

Affiliations

Soon will be listed here.

Abstract

Antiretroviral therapy lowers viral load only when people living with HIV maintain their treatment retention. Lost to follow-up is the persistent major challenge to the success of ART program in low-resource settings including Ethiopia. The purpose of this study is to estimate time to lost to follow-up and its predictors in antiretroviral therapies amongst adult patients. Among registered HIV patients, 542 samples were included. Data cleaning and analysis were done using Stata/SE version 14 software. In multivariable Cox regression, a p-value < 0.05 at 95% confidence interval with corresponding adjusted hazards ratio (AHR) were statistically significant predictors. In this study, the median time to lost to follow-up is 77 months. The incidence density of lost to follow-up was 13.45 (95% CI: 11.78, 15.34) per 100 person-years. Antiretroviral therapy drug adherence [AHR: 3.04 (95% CI: 2.18, 4.24)], last functional status [AHR: 2.74 (95% CI: 2.04, 3.67)], and INH prophylaxis [AHR: 1.65 (95% CI: 1.07, 2.56) were significant predictors for time to lost to follow-up. The median time to lost was 77 months and incidence of lost to follow-up was high. Health care providers should be focused on HIV counseling and proper case management focused on identified risks.

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