Long Non-coding RNA RGMB-AS1 Represses Nasopharyngeal Carcinoma Progression Via Binding to Forkhead Box A1

Overview

Journal Bioengineered

Date 2022 Feb 21

PMID 35184697

Authors

Tian Zhang

Ying Jin

Xiangmei Luo

Affiliations

Soon will be listed here.

Abstract

Long non-coding RNA RGMB-AS1 (RGMB antisense RNA 1) plays a crucial role in tumor progression. However, its underlying mechanism in nasopharyngeal carcinoma (NPC) remains unclear. In this study, we analyzed the clinical significance of lncRNA RGMB-AS1 as a possible potential marker in NPC, and investigated the effect and mechanism of lncRNA RGMB-AS1 on proliferation, migration and epithelial mesenchymal transformation (EMT) of NPC by directly binding Forkhead box A1 (FOXA1) in and in . In conclusion, LncRNA RGMB-AS1 inhibits malignant behaviors and EMT by regulating FOXA1, and lncRNA RGMB-AS1 may be an important indicator of clinical prognosis.

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