Predictive Validity of a Computerized Battery for Identifying Neurocognitive Impairments Among Children Living with HIV in Botswana

Overview

Journal AIDS Behav

Specialty Infectious Diseases

Date 2022 Feb 19

PMID 35182282

Authors

Amelia E Van Pelt

Tyler M Moore

J Cobb Scott

Onkemetse Phoi

Lingani Mbakile-Mahlanza

Knashawn H Morales

Ruben C Gur

Shathani Rampa

Mogomotsi Matshaba

Elizabeth D Lowenthal

Affiliations

Soon will be listed here.

Abstract

Children living with HIV (HIV+) experience increased risk of neurocognitive deficits, but standardized cognitive testing is limited in low-resource, high-prevalence settings. The Penn Computerized Neurocognitive Battery (PennCNB) was adapted for use in Botswana. This study evaluated the criterion validity of a locally adapted version of the PennCNB among a cohort of HIV+ individuals aged 10-17 years in Botswana. Participants completed the PennCNB and a comprehensive professional consensus assessment consisting of pencil-and-paper psychological assessments, clinical interview, and review of academic performance. Seventy-two participants were classified as cases (i.e., with cognitive impairment; N = 48) or controls (i.e., without cognitive impairment; N = 24). Sensitivity, specificity, positive predictive value, negative predictive value, and the area under receiver operating characteristic curves were calculated. Discrimination was acceptable, and prediction improved as the threshold for PennCNB impairment was less conservative. This research contributes to the validation of the PennCNB for use among children affected by HIV in Botswana.

Citing Articles

The Evolution of Assessing Central Nervous System Complications in Human Immunodeficiency Virus: Where Do We Go From Here?.

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PMID: 36930636 PMC: 10022716. DOI: 10.1093/infdis/jiac316.

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