Neuroinflammatory Modulation of Extracellular Vesicle Biogenesis and Cargo Loading

Overview

Journal Neuromolecular Med

Specialty Biochemistry

Date 2022 Feb 19

PMID 35181852

Authors

Jereme G Spiers

Natasha Vassileff

Andrew F Hill

Affiliations

Soon will be listed here.

Abstract

Increasing evidence suggests neuroinflammation is a highly coordinated response involving multiple cell types and utilising several different forms of cellular communication. In addition to the well documented cytokine and chemokine messengers, extracellular vesicles (EVs) have emerged as key regulators of the inflammatory response. EVs act as vectors of intercellular communication, capable of travelling between different cells and tissues to deliver selectively packaged protein, miRNA, and lipids from the parent cell. During neuroinflammation, EVs transmit specific inflammatory mediators, particularly from microglia, to promote inflammatory resolution. This mini-review will highlight the novel neuroinflammatory mechanisms contributing to the biogenesis and selective packaging of EVs.

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