Coronary Arterial Function and Disease in Women With No Obstructive Coronary Arteries

Overview

Journal Circ Res

Specialty Cardiology & Vascular Diseases

Date 2022 Feb 17

PMID 35175840

Authors

Harmony R Reynolds

C Noel Bairey Merz

Colin Berry

Rohit Samuel

Jacqueline Saw

Nathaniel R Smilowitz

Ana Carolina do A H de Souza

Robert Sykes

Viviany R Taqueti

Janet Wei

Affiliations

Soon will be listed here.

Abstract

Ischemic heart disease (IHD) is the leading cause of mortality in women. While traditional cardiovascular risk factors play an important role in the development of IHD in women, women may experience sex-specific IHD risk factors and pathophysiology, and thus female-specific risk stratification is needed for IHD prevention, diagnosis, and treatment. Emerging data from the past 2 decades have significantly improved the understanding of IHD in women, including mechanisms of ischemia with no obstructive coronary arteries and myocardial infarction with no obstructive coronary arteries. Despite this progress, sex differences in IHD outcomes persist, particularly in young women. This review highlights the contemporary understanding of coronary arterial function and disease in women with no obstructive coronary arteries, including coronary anatomy and physiology, mechanisms of ischemia with no obstructive coronary arteries and myocardial infarction with no obstructive coronary arteries, noninvasive and invasive diagnostic strategies, and management of IHD.

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