Matrix-induced Autologous Chondrocyte Implantation (mACI) Versus Autologous Matrix-induced Chondrogenesis (AMIC) for Chondral Defects of the Knee: a Systematic Review

Overview

Journal Br Med Bull

Publisher Oxford University Press

Specialty General Medicine

Date 2022 Feb 17

PMID 35175354

Authors

Filippo Migliorini

Jorg Eschweiler

Christian Gotze

Arne Driessen

Markus Tingart

Nicola Maffulli

Affiliations

Soon will be listed here.

Abstract

Introduction: Chondral defects of the knee are common and their treatment is challenging.

Source Of Data: PubMed, Google scholar, Embase and Scopus databases.

Areas Of Agreement: Both autologous matrix-induced chondrogenesis (AMIC) and membrane-induced autologous chondrocyte implantation (mACI) have been used to manage chondral defects of the knee.

Areas Of Controversy: It is debated whether AMIC and mACI provide equivalent outcomes for the management of chondral defects in the knee at midterm follow-up. Despite the large number of clinical studies, the optimal treatment is still controversial.

Growing Points: To investigate whether AMIC provide superior outcomes than mACI at midterm follow-up.

Areas Timely For Developing Research: AMIC may provide better outcomes than mACI for chondral defects of the knee. Further studies are required to verify these results in a clinical setting.

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