HIV Transmitting Mononuclear Phagocytes; Integrating the Old and New

Overview

Journal Mucosal Immunol

Publisher Elsevier

Specialty Allergy & Immunology

Date 2022 Feb 17

PMID 35173293

Authors

Erica E Vine

Jake W Rhodes

Freja A Warner van Dijk

Scott N Byrne

Kirstie M Bertram

Anthony L Cunningham

Andrew N Harman

Affiliations

Soon will be listed here.

Abstract

In tissue, mononuclear phagocytes (MNP) are comprised of Langerhans cells, dendritic cells, macrophages and monocyte-derived cells. They are the first immune cells to encounter HIV during transmission and transmit the virus to CD4 T cells as a consequence of their antigen presenting cell function. To understand the role these cells play in transmission, their phenotypic and functional characterisation is important. With advancements in high parameter single cell technologies, new MNPs subsets are continuously being discovered and their definition and classification is in a state of flux. This has important implications for our knowledge of HIV transmission, which requires a deeper understanding to design effective vaccines and better blocking strategies. Here we review the historical research of the role MNPs play in HIV transmission up to the present day and revaluate these studies in the context of our most recent understandings of the MNP system.

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