Function of Lipid Binding Proteins of Parasitic Helminths: Still a Long Road

Overview

Journal Parasitol Res

Specialty Parasitology

Date 2022 Feb 16

PMID 35169885

Authors

Jose F Lombardo

Jorge L Porfido

Martin S Sisti

A Nahili Giorello

Santiago Rodriguez

Betina Corsico

Gisela R Franchini

Affiliations

Soon will be listed here.

Abstract

Infections with parasitic helminths cause severe debilitating and sometimes lethal diseases in humans and domestic animals on a global scale. Unable to synthesize de novo their own fatty acids and sterols, helminth parasites (nematodes, trematodes, cestodes) rely on their hosts for their supply. These organisms produce and secrete a wide range of lipid binding proteins that are, in most cases, structurally different from the ones found in their hosts, placing them as possible novel therapeutic targets. In this sense, a lot of effort has been made towards the structure determination of these proteins, but their precise function is still unknown. In this review, we aim to present the current knowledge on the functions of LBPs present in parasitic helminths as well as novel members of this highly heterogeneous group of proteins.

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References

Arend A, Zaha A, Ayala F, Haag K . The Echinococcus granulosus antigen B shows a high degree of genetic variability. Exp Parasitol. 2004; 108(1-2):76-80. DOI: 10.1016/j.exppara.2004.07.009. View

Barf T, Lehmann F, Hammer K, Haile S, Axen E, Medina C . N-Benzyl-indolo carboxylic acids: Design and synthesis of potent and selective adipocyte fatty-acid binding protein (A-FABP) inhibitors. Bioorg Med Chem Lett. 2009; 19(6):1745-8. DOI: 10.1016/j.bmcl.2009.01.084. View

Barletta G, Franchini G, Corsico B, Fernandez-Alberti S . Fatty Acid and Retinol-Binding Protein: Unusual Protein Conformational and Cavity Changes Dictated by Ligand Fluctuations. J Chem Inf Model. 2019; 59(8):3545-3555. DOI: 10.1021/acs.jcim.9b00364. View

Barrett J . Forty years of helminth biochemistry. Parasitology. 2009; 136(12):1633-42. DOI: 10.1017/S003118200900568X. View

Barrett J, Saghir N, Timanova A, Clarke K, Brophy P . Characterisation and properties of an intracellular lipid-binding protein from the tapeworm Moniezia expansa. Eur J Biochem. 1998; 250(2):269-75. DOI: 10.1111/j.1432-1033.1997.0269a.x. View

Basavaraju S, Basavaraju S, Zhan B, Kennedy M, Liu Y, Hawdon J . Ac-FAR-1, a 20 kDa fatty acid- and retinol-binding protein secreted by adult Ancylostoma caninum hookworms: gene transcription pattern, ligand binding properties and structural characterisation. Mol Biochem Parasitol. 2003; 126(1):63-71. DOI: 10.1016/s0166-6851(02)00253-0. View

Becker M, Kalinna B, Waine G, McManus D . Gene cloning, overproduction and purification of a functionally active cytoplasmic fatty acid-binding protein (Sj-FABPC) from the human blood fluke Schistosoma japonicum. Gene. 1994; 148(2):321-5. DOI: 10.1016/0378-1119(94)90706-4. View

Belgamo J, Alberca L, Porfido J, Romero F, Rodriguez S, Talevi A . Application of target repositioning and in silico screening to exploit fatty acid binding proteins (FABPs) from Echinococcus multilocularis as possible drug targets. J Comput Aided Mol Des. 2020; 34(12):1275-1288. DOI: 10.1007/s10822-020-00352-8. View

Blaxter M, Koutsovoulos G . The evolution of parasitism in Nematoda. Parasitology. 2014; 142 Suppl 1:S26-39. PMC: 4413787. DOI: 10.1017/S0031182014000791. View

10.

Bradley J, Nirmalan N, Klager S, Faulkner H, Kennedy M . River blindness: a role for parasite retinoid-binding proteins in the generation of pathology?. Trends Parasitol. 2001; 17(10):471-5. DOI: 10.1016/s1471-4922(01)02036-0. View

11.

Britton C, Moore J, Gilleard J, Kennedy M . Extensive diversity in repeat unit sequences of the cDNA encoding the polyprotein antigen/allergen from the bovine lungworm Dictyocaulus viviparus. Mol Biochem Parasitol. 1995; 72(1-2):77-88. DOI: 10.1016/0166-6851(95)00088-i. View

12.

Britton C, Roberts B, Marks N . Functional Genomics Tools for Haemonchus contortus and Lessons From Other Helminths. Adv Parasitol. 2016; 93:599-623. DOI: 10.1016/bs.apar.2016.02.017. View

13.

Burbelo P, Leahy H, Iadarola M, Nutman T . A four-antigen mixture for rapid assessment of Onchocerca volvulus infection. PLoS Negl Trop Dis. 2009; 3(5):e438. PMC: 2677158. DOI: 10.1371/journal.pntd.0000438. View

14.

Ceol C, Horvitz H . A new class of C. elegans synMuv genes implicates a Tip60/NuA4-like HAT complex as a negative regulator of Ras signaling. Dev Cell. 2004; 6(4):563-76. DOI: 10.1016/s1534-5807(04)00065-6. View

15.

Chemale G, Haag K, Ferreira H, Zaha A . Echinococcus granulosus antigen B is encoded by a gene family. Mol Biochem Parasitol. 2001; 116(2):233-7. DOI: 10.1016/s0166-6851(01)00316-4. View

16.

Cheng X, Xiang Y, Xie H, Xu C, Xie T, Zhang C . Molecular characterization and functions of fatty acid and retinoid binding protein gene (Ab-far-1) in Aphelenchoides besseyi. PLoS One. 2013; 8(6):e66011. PMC: 3673936. DOI: 10.1371/journal.pone.0066011. View

17.

Eiras J, Zhu X, Yurlova N, Pedrassani D, Yoshikawa M, Nawa Y . Dioctophyme renale (Goeze, 1782) (Nematoda, Dioctophymidae) parasitic in mammals other than humans: A comprehensive review. Parasitol Int. 2020; 81:102269. DOI: 10.1016/j.parint.2020.102269. View

18.

Esteves A, Dallagiovanna B, Ehrlich R . A developmentally regulated gene of Echinococcus granulosus codes for a 15.5-kilodalton polypeptide related to fatty acid binding proteins. Mol Biochem Parasitol. 1993; 58(2):215-22. DOI: 10.1016/0166-6851(93)90043-w. View

19.

Estuningsih S, Smooker P, Wiedosari E, Widjajanti S, Vaiano S, Partoutomo S . Evaluation of antigens of Fasciola gigantica as vaccines against tropical fasciolosis in cattle. Int J Parasitol. 1998; 27(11):1419-28. DOI: 10.1016/s0020-7519(97)00096-9. View

20.

Fairfax K, Vermeire J, Harrison L, Bungiro R, Grant W, Husain S . Characterisation of a fatty acid and retinol binding protein orthologue from the hookworm Ancylostoma ceylanicum. Int J Parasitol. 2009; 39(14):1561-71. PMC: 2760681. DOI: 10.1016/j.ijpara.2009.06.005. View