Eu Doped TiC Quantum Dots to Form a Ratiometric Fluorescence Platform for Visual and Quantitative Point-of-care Testing of Tetracycline Derivatives

Antibiotic residues have become a public health issues, the fast detection of tetracycline (Tc) in the environment is urgently required. In this work, TiC quantum dots (TiC QDs) and Europium ions jointly constructed a ratiometric fluorescence (FL) platform for the detection of Tc, based on synergistic impact of the Foster Resonance Energy Transfer (FRET) from TiC QDs to Eu ions and the Antenna Effect (AE) between Tc and Eu ions. And we proposed a ratiometric FL platform for detecting Tc with good linear response range (100-1000 uM) and low detection limit (48.79 nM). Meanwhile, we applied this platform to detect a serious of β-diketone ligands of Eu ions, demonstrating the platform's versatility for this category of chemical. Furthermore, based on the color changes of QDs@Eu from blue to red at 365 nm ultraviolet light, an intelligent detection smart device was built for the visual semi-quantitative detection of Tc in actual samples. We proved the applicability of the device in complicated samples and the potential for rapid, sensitive, intuitive and point-of-care detection in the field of environment, food, pharmaceutical and agriculture.