» Articles » PMID: 35167950

Ocular Surface Disease in Thyroid Eye Disease: A Narrative Review

Overview
Journal Ocul Surf
Specialty Ophthalmology
Date 2022 Feb 15
PMID 35167950
Authors
Affiliations
Soon will be listed here.
Abstract

Ocular surface disease (OSD) in the setting of thyroid eye disease (TED) is traditionally thought of as a natural consequence of anatomical changes such as proptosis and corneal exposure. However, a growing body of research suggests that ocular surface inflammation and multi-factorial changes to the homeostasis of the ocular surface contribute substantially to the OSD seen in TED patients. In this paper we review the existing literature which highlights the work and existing theories underlying this new paradigm shift.

Citing Articles

Research progress on the immune mechanism of thyroid-related eye disease combined with dry eye.

Wang Y, Chen D, Jin L, Li D J Ophthalmic Inflamm Infect. 2025; 15(1):23.

PMID: 40063329 PMC: 11893917. DOI: 10.1186/s12348-025-00477-7.


Eyeball descending identification using MRI-based spatial coordinates in thyroid-associated orbitopathy patients with unilateral upper eyelid retraction.

Gou X, Wang Y, Li T, Zhou L, Lian J, Zhang X Quant Imaging Med Surg. 2025; 15(2):1287-1296.

PMID: 39995720 PMC: 11847195. DOI: 10.21037/qims-24-1659.


Ocular surface disease index in Graves' orbitopathy: a cross-sectional study.

Maglionico M, Lanzolla G, Figus M, Cosentino G, Comi S, Marino M Front Endocrinol (Lausanne). 2024; 15:1428185.

PMID: 39713053 PMC: 11659954. DOI: 10.3389/fendo.2024.1428185.


A Comprehensive Review of Thyroid Eye Disease Pathogenesis: From Immune Dysregulations to Novel Diagnostic and Therapeutic Approaches.

Kulbay M, Tanya S, Tuli N, Dahoud J, Dahoud A, Alsaleh F Int J Mol Sci. 2024; 25(21).

PMID: 39519180 PMC: 11546489. DOI: 10.3390/ijms252111628.


Thyroid Eye Disease: Advancements in Orbital and Ocular Pathology Management.

Scarabosio A, Surico P, Singh R, Tereshenko V, Musa M, DEsposito F J Pers Med. 2024; 14(7).

PMID: 39064030 PMC: 11278049. DOI: 10.3390/jpm14070776.


References
1.
Douglas R, Kahaly G, Patel A, Sile S, Thompson E, Perdok R . Teprotumumab for the Treatment of Active Thyroid Eye Disease. N Engl J Med. 2020; 382(4):341-352. DOI: 10.1056/NEJMoa1910434. View

2.
Feldmann M, Brennan F, Chantry D, Haworth C, Turner M, Katsikis P . Cytokine assays: role in evaluation of the pathogenesis of autoimmunity. Immunol Rev. 1991; 119:105-23. DOI: 10.1111/j.1600-065x.1991.tb00580.x. View

3.
Achtsidis V, Tentolouris N, Theodoropoulou S, Panagiotidis D, Vaikoussis E, Saldana M . Dry eye in Graves ophthalmopathy: correlation with corneal hypoesthesia. Eur J Ophthalmol. 2013; 23(4):473-9. DOI: 10.5301/ejo.5000259. View

4.
Tomlinson A, Khanal S, Ramaesh K, Diaper C, McFadyen A . Tear film osmolarity: determination of a referent for dry eye diagnosis. Invest Ophthalmol Vis Sci. 2006; 47(10):4309-15. DOI: 10.1167/iovs.05-1504. View

5.
Craig J, Nichols K, Akpek E, Caffery B, Dua H, Joo C . TFOS DEWS II Definition and Classification Report. Ocul Surf. 2017; 15(3):276-283. DOI: 10.1016/j.jtos.2017.05.008. View