Pericentromeric Repetitive NcRNA Regulates Chromatin Interaction and Inflammatory Gene Expression

Overview

Journal Nucleus

Date 2022 Feb 15

PMID 35167425

Authors

Kenichi Miyata

Akiko Takahashi

Affiliations

Soon will be listed here.

Abstract

Cellular senescence provokes a dramatic alteration of chromatin organization and gene expression profile of proinflammatory factors, thereby contributing to various age-related pathologies via the senescence-associated secretory phenotype (SASP). Chromatin organization and global gene expression are maintained through the CCCTC-binding factor (CTCF). However, the molecular mechanism underlying CTCF regulation and its association with SASP gene expression remains to be fully elucidated. A recent study by our team showed that noncoding RNA (ncRNA) derived from normally silenced pericentromeric repetitive sequences directly impair the DNA binding of CTCF. This CTCF disturbance increases the accessibility of chromatin at the loci of SASP genes and caused the transcription of inflammatory factors. This mechanism may promote malignant transformation.

Citing Articles

Chromatin conformational changes at human satellite II contribute to the senescence phenotype in the tumor microenvironment.

Miyata K, Zhou X, Nishio M, Hanyu A, Chiba M, Kawasaki H Proc Natl Acad Sci U S A. 2023; 120(32):e2305046120.

PMID: 37523559 PMC: 10410700. DOI: 10.1073/pnas.2305046120.

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