Seasonal Chemical Evaluation of Naudin from Brazilian Savanna

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2022 Feb 15

PMID 35164385

Authors

Juliana de Freitas Ferreira

Manuel Humberto Mera Lopez

Joao Victor Dutra Gomes

Diegue H Nascimento Martins

Christopher William Fagg

Perola Oliveira Magalhaes

Noel William Davies

Damaris Silveira

Yris Maria Fonseca-Bazzo

Affiliations

Soon will be listed here.

Abstract

Naudin is a species from the Cerrado, which is being increasingly researched for its therapeutic potential. The aim of this study was to obtain a standardized extract and to evaluate seasonal chemical variations. Seven batches of aqueous extracts from leaves were produced for the standardization. These extracts were evaluated for total solids, polyphenol (TPC) and flavonoid content (TFC), vitexin derivative content, antioxidant activity; thin-layer chromatography (TLC), and high-performance liquid chromatography (HPLC) profiles were generated. For the seasonal study, leaves were collected from five different periods (May 2017 to August 2018). The results were correlated with meteorological data (global radiation, temperature, and rainfall index). Using chromatographic and spectroscopic techniques, apigenin C-glycosides (vitexin/isovitexin) and derivatives, luteolin C-glycosides (orientin/isoorientin) and derivatives, a quercetin glycoside, miconioside B, matteucinol-7--β-apiofuranosyl (1 → 6) -β-glucopyranoside, and farrerol were identified. Quality parameters, including chemical marker quantification by HPLC, and biological activity, are described. In the extract standardization process, all the evaluated parameters showed low variability. The seasonality study revealed no significant correlations ( < 0.05) between TPC or TFC content and meteorological data. These results showed that it is possible to obtain extracts from at any time of the year without significant differences in composition.

Citing Articles

Does (L.) Blume Produce Cannabinoids?.

Oliveira G, Estrada-Semprun O, Arantes L, Rodrigues P, Ribeiro R, Fagg C Plants (Basel). 2024; 13(14).

PMID: 39065478 PMC: 11281079. DOI: 10.3390/plants13141951.

Special Issue-"Isolation, Structure Elucidation and Biological Activity of Natural Products".

Takahashi J Molecules. 2023; 28(14).

PMID: 37513264 PMC: 10383114. DOI: 10.3390/molecules28145392.

Bio-Prospecting of Crude Leaf Extracts from Thirteen Plants of Brazilian Cerrado Biome on Human Glioma Cell Lines.

Silva V, Rosa M, Gomes I, Vital P, Alves A, Evangelista A Molecules. 2023; 28(3).

PMID: 36771057 PMC: 9921846. DOI: 10.3390/molecules28031394.

References

Dhalla N, Temsah R, Netticadan T . Role of oxidative stress in cardiovascular diseases. J Hypertens. 2000; 18(6):655-73. DOI: 10.1097/00004872-200018060-00002. View

Ishino M, De Sibio P, Rossi M . Edge effect and phenology in Erythroxylum tortuosum (Erythroxylaceae), a typical plant of the Brazilian Cerrado. Braz J Biol. 2012; 72(3):587-94. DOI: 10.1590/s1519-69842012000300023. View

Calderon A, Simithy-Williams J, Gupta M . Antimalarial natural products drug discovery in Panama. Pharm Biol. 2011; 50(1):61-71. DOI: 10.3109/13880209.2011.602417. View

Costa Gontijo D, Gontijo P, Brandao G, Alves Nogueira Diaz M, Braga de Oliveira A, Fietto L . Antioxidant study indicative of antibacterial and antimutagenic activities of an ellagitannin-rich aqueous extract from the leaves of Miconia latecrenata. J Ethnopharmacol. 2019; 236:114-123. DOI: 10.1016/j.jep.2019.03.007. View

Prieto P, Pineda M, Aguilar M . Spectrophotometric quantitation of antioxidant capacity through the formation of a phosphomolybdenum complex: specific application to the determination of vitamin E. Anal Biochem. 1999; 269(2):337-41. DOI: 10.1006/abio.1999.4019. View

Emerit J, Edeas M, Bricaire F . Neurodegenerative diseases and oxidative stress. Biomed Pharmacother. 2004; 58(1):39-46. DOI: 10.1016/j.biopha.2003.11.004. View

Luo J, Mills K, le Cessie S, Noordam R, van Heemst D . Ageing, age-related diseases and oxidative stress: What to do next?. Ageing Res Rev. 2019; 57:100982. DOI: 10.1016/j.arr.2019.100982. View

Kazuno S, Yanagida M, Shindo N, Murayama K . Mass spectrometric identification and quantification of glycosyl flavonoids, including dihydrochalcones with neutral loss scan mode. Anal Biochem. 2005; 347(2):182-92. DOI: 10.1016/j.ab.2005.09.020. View

Vukics V, Ringer T, Kery A, Bonn G, Guttman A . Analysis of heartsease (Viola tricolor L.) flavonoid glycosides by micro-liquid chromatography coupled to multistage mass spectrometry. J Chromatogr A. 2008; 1206(1):11-20. DOI: 10.1016/j.chroma.2008.05.017. View

10.

Cherfia R, Zaiter A, Akkal S, Chaimbault P, Abdelwahab A, Kirsch G . New approach in the characterization of bioactive compounds isolated from Calycotome spinosa (L.) Link leaves by the use of negative electrospray ionization LITMS, LC-ESI-MS/MS, as well as NMR analysis. Bioorg Chem. 2020; 96:103535. DOI: 10.1016/j.bioorg.2019.103535. View

11.

Wojakowska A, Perkowski J, Goral T, Stobiecki M . Structural characterization of flavonoid glycosides from leaves of wheat (Triticum aestivum L.) using LC/MS/MS profiling of the target compounds. J Mass Spectrom. 2013; 48(3):329-39. DOI: 10.1002/jms.3160. View

12.

Yang X, Yang L, Xiong A, Li D, Wang Z . Authentication of Senecio scandens and S. vulgaris based on the comprehensive secondary metabolic patterns gained by UPLC-DAD/ESI-MS. J Pharm Biomed Anal. 2011; 56(2):165-72. DOI: 10.1016/j.jpba.2011.05.004. View

13.

Tarawneh A, Leon F, Ibrahim M, Pettaway S, McCurdy C, Cutler S . Flavanones from . Phytochem Lett. 2014; 7:130-132. PMC: 4070512. DOI: 10.1016/j.phytol.2013.11.001. View

14.

Vukics V, Guttman A . Structural characterization of flavonoid glycosides by multi-stage mass spectrometry. Mass Spectrom Rev. 2009; 29(1):1-16. DOI: 10.1002/mas.20212. View

15.

Li S, Tan H, Wang N, Zhang Z, Lao L, Wong C . The Role of Oxidative Stress and Antioxidants in Liver Diseases. Int J Mol Sci. 2015; 16(11):26087-124. PMC: 4661801. DOI: 10.3390/ijms161125942. View

16.

Zhang Z, ElSohly H, Li X, Khan S, Broedel Jr S, Raulli R . Flavanone glycosides from Miconia trailii. J Nat Prod. 2003; 66(1):39-41. DOI: 10.1021/np020429z. View

17.

Zheng W, Ren Y, Wu M, Yang Y, Fan Y, Piao X . A review of the traditional uses, phytochemistry and biological activities of the Melastoma genus. J Ethnopharmacol. 2020; 264:113322. DOI: 10.1016/j.jep.2020.113322. View

18.

Zanatta A, Vilegas W, Edrada-Ebel R . UHPLC-(ESI)-HRMS and NMR-Based Metabolomics Approach to Access the Seasonality of and From Brazilian Cerrado Flora Diversity. Front Chem. 2021; 9:710025. PMC: 8290060. DOI: 10.3389/fchem.2021.710025. View

19.

. WHO Expert Committee on Specifications for Pharmaceutical Preparations. Fiftieth report. World Health Organ Tech Rep Ser. 2016; (996):1-358, back cover. View

20.

Sun Y, Zhang X, Xue X, Zhang Y, Xiao H, Liang X . Rapid identification of polyphenol C-glycosides from Swertia franchetiana by HPLC-ESI-MS-MS. J Chromatogr Sci. 2009; 47(3):190-6. DOI: 10.1093/chromsci/47.3.190. View