Visible-Light-Induced, Graphene Oxide-Promoted C3-Chalcogenylation of Indoles Strategy Under Transition-Metal-Free Conditions

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2022 Feb 15

PMID 35164036

Authors

Qing Huang

Xiangjun Peng

Hong Li

Haiping He

Liangxian Liu

Affiliations

Soon will be listed here.

Abstract

An efficient and general method for the synthesis of 3-sulfenylindoles and 3-selenylindoles employing visible-light irradiation with graphene oxide as a promoter at room temperature has been achieved. The reaction features are high yields, simple operation, metal-free and iodine-free conditions, an easy-to-handle oxidant, and gram-scalable synthesis. This simple protocol allows one to access a wide range of 3-arylthioindoles, 3-arylselenylindoles, and even 3-thiocyanatoindoles with good to excellent yields.

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