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A Comprehensive Review on the Techniques for Extraction of Bioactive Compounds from Medicinal Cannabis

Overview
Journal Molecules
Publisher MDPI
Specialty Biology
Date 2022 Feb 15
PMID 35163863
Authors
Affiliations
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Abstract

is well-known for its numerous therapeutic activities, as demonstrated in pre-clinical and clinical studies primarily due to its bioactive compounds. The industry is rapidly growing; therefore, product development and extraction methods have become crucial aspects of research. The evaluation of the current extraction methods implemented in the industry and scientific literature to produce consistent, reliable, and potent medicinal extracts is prudent. Furthermore, these processes must be subjected to higher levels of scientific stringency, as has been increasingly used for various ailments, and the industry is receiving acceptance in different countries. We comprehensively analysed the current literature and drew a critical summary of the extraction methods implemented thus far to recover bioactive compounds from medicinal . Moreover, this review outlines the major bioactive compounds in , discusses critical factors affecting extraction yields, and proposes future considerations for the effective extraction of bioactive compounds from . Overall, research on medicinal marijuana is limited, with most reports on the industrial hemp variety of or pure isolates. We also propose the development of sustainable extraction methods through the implementation of mathematical prediction models in future studies.

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References
1.
Rohleder C, Pahlisch F, Graf R, Endepols H, Leweke F . Different pharmaceutical preparations of Δ -tetrahydrocannabinol differentially affect its behavioral effects in rats. Addict Biol. 2019; 25(3):e12745. DOI: 10.1111/adb.12745. View

2.
Xi J . Ultrahigh pressure extraction of bioactive compounds from plants-A review. Crit Rev Food Sci Nutr. 2015; 57(6):1097-1106. DOI: 10.1080/10408398.2013.874327. View

3.
Ahmed M, Ramachandraiah K, Jiang G, Eun J . Effects of Ultra-Sonication and Agitation on Bioactive Compounds and Structure of Amaranth Extract. Foods. 2020; 9(8). PMC: 7466107. DOI: 10.3390/foods9081116. View

4.
Mustafa A, Turner C . Pressurized liquid extraction as a green approach in food and herbal plants extraction: A review. Anal Chim Acta. 2011; 703(1):8-18. DOI: 10.1016/j.aca.2011.07.018. View

5.
Micalizzi G, Vento F, Alibrando F, Donnarumma D, Dugo P, Mondello L . Cannabis Sativa L.: a comprehensive review on the analytical methodologies for cannabinoids and terpenes characterization. J Chromatogr A. 2021; 1637:461864. DOI: 10.1016/j.chroma.2020.461864. View