Recent Advance in Biological Responsive Nanomaterials for Biosensing and Molecular Imaging Application

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2022 Feb 15

PMID 35163845

Authors

Zhenqi Jiang

Xiao Han

Chen Zhao

Shanshan Wang

Xiaoying Tang

Affiliations

Soon will be listed here.

Abstract

In recent decades, as a subclass of biomaterials, biologically sensitive nanoparticles have attracted increased scientific interest. Many of the demands for physiologically responsive nanomaterials in applications involving the human body cannot be met by conventional technologies. Due to the field's importance, considerable effort has been expended, and biologically responsive nanomaterials have achieved remarkable success thus far. This review summarizes the recent advancements in biologically responsive nanomaterials and their applications in biosensing and molecular imaging. The nanomaterials change their structure or increase the chemical reaction ratio in response to specific bio-relevant stimuli (such as pH, redox potentials, enzyme kinds, and concentrations) in order to improve the signal for biologically responsive diagnosis. We use various case studies to illustrate the existing issues and provide a clear sense of direction in this area. Furthermore, the limitations and prospects of these nanomaterials for diagnosis are also discussed.

Citing Articles

AI-Optimized Lattice Structures for Biomechanics Scaffold Design.

Omigbodun F, Oladapo B Biomimetics (Basel). 2025; 10(2).

PMID: 39997111 PMC: 11853473. DOI: 10.3390/biomimetics10020088.

Challenges issues and future recommendations of deep learning techniques for SARS-CoV-2 detection utilising X-ray and CT images: a comprehensive review.

Islam M, Al Farid F, Shamrat F, Islam M, Rashid M, Bari B PeerJ Comput Sci. 2025; 10:e2517.

PMID: 39896401 PMC: 11784792. DOI: 10.7717/peerj-cs.2517.

Luffa-Ni/Al layered double hydroxide bio-nanocomposite for efficient ibuprofen removal from aqueous solution: Kinetic, equilibrium, thermodynamic studies and GEP modeling.

Tavassoli S, Mollahosseini A, Damiri S, Samadi M Heliyon. 2025; 11(1):e40783.

PMID: 39758375 PMC: 11699376. DOI: 10.1016/j.heliyon.2024.e40783.

Bicubic regression analysis a novel approach for estimation of physicochemical properties of skin cancer drugs through degree based entropy.

Hakami K, Khan A, Zia I Heliyon. 2024; 10(20):e39084.

PMID: 39640615 PMC: 11620050. DOI: 10.1016/j.heliyon.2024.e39084.

Advancements in Exosome Proteins for Breast Cancer Diagnosis and Detection: With a Focus on Nanotechnology.

Saadh M, Al-Rihaymee A, Kaur M, Kumar A, Mutee A, Ismaeel G AAPS PharmSciTech. 2024; 25(8):276.

PMID: 39604642 DOI: 10.1208/s12249-024-02983-8.

References

Wu J, Li S, Wei H . Integrated nanozymes: facile preparation and biomedical applications. Chem Commun (Camb). 2018; 54(50):6520-6530. DOI: 10.1039/C8CC01202D. View

Sun T, Zhang Y, Pang B, Hyun D, Yang M, Xia Y . Engineered nanoparticles for drug delivery in cancer therapy. Angew Chem Int Ed Engl. 2014; 53(46):12320-64. DOI: 10.1002/anie.201403036. View

Liu C, Wang D, Zhan Y, Yan L, Lu Q, Chang M . Switchable Photoacoustic Imaging of Glutathione Using MnO Nanotubes for Cancer Diagnosis. ACS Appl Mater Interfaces. 2018; 10(51):44231-44239. DOI: 10.1021/acsami.8b14944. View

Du J, Du X, Mao C, Wang J . Tailor-made dual pH-sensitive polymer-doxorubicin nanoparticles for efficient anticancer drug delivery. J Am Chem Soc. 2011; 133(44):17560-3. DOI: 10.1021/ja207150n. View

Abdukayum A, Yang C, Zhao Q, Chen J, Dong L, Yan X . Gadolinium complexes functionalized persistent luminescent nanoparticles as a multimodal probe for near-infrared luminescence and magnetic resonance imaging in vivo. Anal Chem. 2014; 86(9):4096-101. DOI: 10.1021/ac500644x. View

Jiang Z, Tian Y, Shan D, Wang Y, Gerhard E, Xia J . pH protective Y receptor ligand functionalized antiphagocytosis BPLP-WPU micelles for enhanced tumor imaging and therapy with prolonged survival time. Biomaterials. 2018; 170:70-81. DOI: 10.1016/j.biomaterials.2018.04.002. View

Tripathi A, Saravanan S, Pattnaik S, Moorthi A, Partridge N, Selvamurugan N . Bio-composite scaffolds containing chitosan/nano-hydroxyapatite/nano-copper-zinc for bone tissue engineering. Int J Biol Macromol. 2011; 50(1):294-9. DOI: 10.1016/j.ijbiomac.2011.11.013. View

Wang D, Jana D, Zhao Y . Metal-Organic Framework Derived Nanozymes in Biomedicine. Acc Chem Res. 2020; 53(7):1389-1400. DOI: 10.1021/acs.accounts.0c00268. View

Li F, Liang Z, Liu J, Sun J, Hu X, Zhao M . Dynamically Reversible Iron Oxide Nanoparticle Assemblies for Targeted Amplification of T1-Weighted Magnetic Resonance Imaging of Tumors. Nano Lett. 2019; 19(7):4213-4220. DOI: 10.1021/acs.nanolett.8b04411. View

10.

Lutz J, Akdemir O, Hoth A . Point by point comparison of two thermosensitive polymers exhibiting a similar LCST: is the age of poly(NIPAM) over?. J Am Chem Soc. 2006; 128(40):13046-7. DOI: 10.1021/ja065324n. View

11.

Liu H, Hu X, Li K, Liu Y, Rong Q, Zhu L . A mitochondrial-targeted prodrug for NIR imaging guided and synergetic NIR photodynamic-chemo cancer therapy. Chem Sci. 2018; 8(11):7689-7695. PMC: 5861986. DOI: 10.1039/c7sc03454g. View

12.

Liu P, Li B, Zhan C, Zeng F, Wu S . A two-photon-activated prodrug for therapy and drug release monitoring. J Mater Chem B. 2020; 5(36):7538-7546. DOI: 10.1039/c7tb01408b. View

13.

Yang H, Wang Z, Li C, Xu C . Nanoporous PdCu alloy as an excellent electrochemical sensor for HO and glucose detection. J Colloid Interface Sci. 2017; 491:321-328. DOI: 10.1016/j.jcis.2016.12.041. View

14.

Wu Y, Fan Q, Zeng F, Zhu J, Chen J, Fan D . Peptide-Functionalized Nanoinhibitor Restrains Brain Tumor Growth by Abrogating Mesenchymal-Epithelial Transition Factor (MET) Signaling. Nano Lett. 2018; 18(9):5488-5498. DOI: 10.1021/acs.nanolett.8b01879. View

15.

Chung C, Kim Y, Shin D, Ryoo S, Hong B, Min D . Biomedical applications of graphene and graphene oxide. Acc Chem Res. 2013; 46(10):2211-24. DOI: 10.1021/ar300159f. View

16.

Weber J, Beard P, Bohndiek S . Contrast agents for molecular photoacoustic imaging. Nat Methods. 2016; 13(8):639-50. DOI: 10.1038/nmeth.3929. View

17.

Li X, Li K, Chu F, Huang J, Yang Z . Graphene oxide enhances β-amyloid clearance by inducing autophagy of microglia and neurons. Chem Biol Interact. 2020; 325:109126. DOI: 10.1016/j.cbi.2020.109126. View

18.

Zhai L . Stimuli-responsive polymer films. Chem Soc Rev. 2013; 42(17):7148-60. DOI: 10.1039/c3cs60023h. View

19.

Nayak T, Andersen H, Makam V, Khaw C, Bae S, Xu X . Graphene for controlled and accelerated osteogenic differentiation of human mesenchymal stem cells. ACS Nano. 2011; 5(6):4670-8. DOI: 10.1021/nn200500h. View

20.

Rodriguez-Hernandez J, Lecommandoux S . Reversible inside-out micellization of pH-responsive and water-soluble vesicles based on polypeptide diblock copolymers. J Am Chem Soc. 2005; 127(7):2026-7. DOI: 10.1021/ja043920g. View