Lifestyle Factors Involved in the Pathogenesis of Alopecia Areata

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2022 Feb 15

PMID 35162962

Authors

Yoko Minokawa

Yu Sawada

Motonobu Nakamura

Affiliations

Soon will be listed here.

Abstract

Alopecia areata is a representative inflammatory skin disease that is associated with various environmental stimuli. While psychological stress is believed to be a major pathogenetic trigger in alopecia areata, infants and newborns also suffer from the disease, suggesting the possible presence of other environmental factors. Daily lifestyle is well known to be involved in various inflammatory diseases and influences the severity of inflammatory skin diseases. However, only a limited number of studies have summarized these influences on alopecia areata. In this review article, we summarize lifestyle factor-related influences on the pathogenesis of alopecia areata and focus on environmental factors, such as smoking, alcohol consumption, sleep, obesity, fatty acids, and gluten consumption.

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References

Dai Y, Tai Y, Chen C, Chang Y, Chen T, Chen M . Bidirectional association between alopecia areata and sleep disorders: a population-based cohort study in Taiwan. Sleep Med. 2020; 75:112-116. DOI: 10.1016/j.sleep.2020.06.015. View

Takita E, Yokota S, Tahara Y, Hirao A, Aoki N, Nakamura Y . Biological clock dysfunction exacerbates contact hypersensitivity in mice. Br J Dermatol. 2012; 168(1):39-46. DOI: 10.1111/j.1365-2133.2012.11176.x. View

Kim S, Akindehin S, Kwon H, Son Y, Saha A, Jung Y . Anti-inflammatory role of 15-lipoxygenase contributes to the maintenance of skin integrity in mice. Sci Rep. 2018; 8(1):8856. PMC: 5995961. DOI: 10.1038/s41598-018-27221-7. View

Ito T, Ito N, Saatoff M, Hashizume H, Fukamizu H, Nickoloff B . Maintenance of hair follicle immune privilege is linked to prevention of NK cell attack. J Invest Dermatol. 2007; 128(5):1196-206. DOI: 10.1038/sj.jid.5701183. View

El-Morsy E, Eid A, Ghoneim H, Al-Tameemi K . Serum level of interleukin-17A in patients with alopecia areata and its relationship to age. Int J Dermatol. 2015; 55(8):869-74. DOI: 10.1111/ijd.12994. View

Addolorato G, Parente A, de Lorenzi G, Dangelo Di Paola M, Abenavoli L, Leggio L . Rapid regression of psoriasis in a coeliac patient after gluten-free diet. A case report and review of the literature. Digestion. 2003; 68(1):9-12. DOI: 10.1159/000073220. View

Gardner K, Gebretsadik T, Hartman T, Rosa M, Tylavsky F, Adgent M . Prenatal Omega-3 and Omega-6 Polyunsaturated Fatty Acids and Childhood Atopic Dermatitis. J Allergy Clin Immunol Pract. 2019; 8(3):937-944. PMC: 7064417. DOI: 10.1016/j.jaip.2019.09.031. View

Kemp E, Sandhu H, Weetman A, McDonagh A . Demonstration of autoantibodies against tyrosine hydroxylase in patients with alopecia areata. Br J Dermatol. 2011; 165(6):1236-43. DOI: 10.1111/j.1365-2133.2011.10597.x. View

Oyoshi M, He R, Li Y, Mondal S, Yoon J, Afshar R . Leukotriene B4-driven neutrophil recruitment to the skin is essential for allergic skin inflammation. Immunity. 2012; 37(4):747-58. PMC: 3478399. DOI: 10.1016/j.immuni.2012.06.018. View

10.

Corazza G, Andreani M, Venturo N, Bernardi M, Tosti A, Gasbarrini G . Celiac disease and alopecia areata: report of a new association. Gastroenterology. 1995; 109(4):1333-7. DOI: 10.1016/0016-5085(95)90597-9. View

11.

Horrobin D . Low prevalences of coronary heart disease (CHD), psoriasis, asthma and rheumatoid arthritis in Eskimos: are they caused by high dietary intake of eicosapentaenoic acid (EPA), a genetic variation of essential fatty acid (EFA) metabolism or a.... Med Hypotheses. 1987; 22(4):421-8. DOI: 10.1016/0306-9877(87)90037-5. View

12.

Sillaber I, Henniger M . Stress and alcohol drinking. Ann Med. 2005; 36(8):596-605. DOI: 10.1080/07853890410018862. View

13.

Shimizu T, Mizue Y, Abe R, Watanabe H, Shimizu H . Increased macrophage migration inhibitory factor (MIF) in the sera of patients with extensive alopecia areata. J Invest Dermatol. 2002; 118(3):555-7. DOI: 10.1046/j.0022-202x.2001.01669.x. View

14.

Nakamizo S, Honda T, Adachi A, Nagatake T, Kunisawa J, Kitoh A . High fat diet exacerbates murine psoriatic dermatitis by increasing the number of IL-17-producing γδ T cells. Sci Rep. 2017; 7(1):14076. PMC: 5658347. DOI: 10.1038/s41598-017-14292-1. View

15.

Juarez-Rendon K, Rivera Sanchez G, Reyes-Lopez M, Garcia-Ortiz J, Bocanegra-Garcia V, Guardiola-Avila I . Alopecia Areata. Current situation and perspectives. Arch Argent Pediatr. 2017; 115(6):e404-e411. DOI: 10.5546/aap.2017.eng.e404. View

16.

Sawada Y, Gallo R . Role of Epigenetics in the Regulation of Immune Functions of the Skin. J Invest Dermatol. 2020; 141(5):1157-1166. PMC: 8068568. DOI: 10.1016/j.jid.2020.10.012. View

17.

Budu-Aggrey A, Brumpton B, Tyrrell J, Watkins S, Modalsli E, Celis-Morales C . Evidence of a causal relationship between body mass index and psoriasis: A mendelian randomization study. PLoS Med. 2019; 16(1):e1002739. PMC: 6354959. DOI: 10.1371/journal.pmed.1002739. View

18.

Sawada Y, Saito-Sasaki N, Nakamura M . Omega 3 Fatty Acid and Skin Diseases. Front Immunol. 2021; 11:623052. PMC: 7892455. DOI: 10.3389/fimmu.2020.623052. View

19.

Ciacci C, Cavallaro R, Iovino P, Sabbatini F, Palumbo A, Amoruso D . Allergy prevalence in adult celiac disease. J Allergy Clin Immunol. 2004; 113(6):1199-203. DOI: 10.1016/j.jaci.2004.03.012. View

20.

Kim T, Kim G, Jin Y, Park Y, Park C . Omega-3 fatty acid-derived mediator, Resolvin E1, ameliorates 2,4-dinitrofluorobenzene-induced atopic dermatitis in NC/Nga mice. Int Immunopharmacol. 2012; 14(4):384-91. DOI: 10.1016/j.intimp.2012.08.005. View