Improving Polysaccharide-Based Chitin/Chitosan-Aerogel Materials by Learning from Genetics and Molecular Biology

Overview

Journal Materials (Basel)

Publisher MDPI

Date 2022 Feb 15

PMID 35160985

Authors

Matthias Behr

Kathirvel Ganesan

Affiliations

Soon will be listed here.

Abstract

Improved wound healing of burnt skin and skin lesions, as well as medical implants and replacement products, requires the support of synthetical matrices. Yet, producing synthetic biocompatible matrices that exhibit specialized flexibility, stability, and biodegradability is challenging. Synthetic chitin/chitosan matrices may provide the desired advantages for producing specialized grafts but must be modified to improve their properties. Synthetic chitin/chitosan hydrogel and aerogel techniques provide the advantages for improvement with a bioinspired view adapted from the natural molecular toolbox. To this end, animal genetics provide deep knowledge into which molecular key factors decisively influence the properties of natural chitin matrices. The genetically identified proteins and enzymes control chitin matrix assembly, architecture, and degradation. Combining synthetic chitin matrices with critical biological factors may point to the future direction with engineering materials of specific properties for biomedical applications such as burned skin or skin blistering and extensive lesions due to genetic diseases.

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References

Peluso G, Petillo O, Ranieri M, Santin M, Ambrosio L, Calabro D . Chitosan-mediated stimulation of macrophage function. Biomaterials. 1994; 15(15):1215-20. DOI: 10.1016/0142-9612(94)90272-0. View

Wang Y, Farine J, Yang Y, Yang J, Tang W, Gehring N . Transcriptional Control of Quality Differences in the Lipid-Based Cuticle Barrier in and . Front Genet. 2020; 11:887. PMC: 7423992. DOI: 10.3389/fgene.2020.00887. View

Yusof N, Wee A, Lim L, Khor E . Flexible chitin films as potential wound-dressing materials: wound model studies. J Biomed Mater Res A. 2003; 66(2):224-32. DOI: 10.1002/jbm.a.10545. View

GEYER G . Lysozyme in Paneth cell secretions. Acta Histochem. 1973; 45(1):126-32. View

Cui L, Xiong Z, Guo Y, Liu Y, Zhao J, Zhang C . Fabrication of interpenetrating polymer network chitosan/gelatin porous materials and study on dye adsorption properties. Carbohydr Polym. 2015; 132:330-7. DOI: 10.1016/j.carbpol.2015.06.017. View

Muthukrishnan S, Mun S, Noh M, Geisbrecht E, Arakane Y . Insect Cuticular Chitin Contributes to Form and Function. Curr Pharm Des. 2020; 26(29):3530-3545. PMC: 7755156. DOI: 10.2174/1381612826666200523175409. View

Jasrapuria S, Specht C, Kramer K, Beeman R, Muthukrishnan S . Gene families of cuticular proteins analogous to peritrophins (CPAPs) in Tribolium castaneum have diverse functions. PLoS One. 2012; 7(11):e49844. PMC: 3504105. DOI: 10.1371/journal.pone.0049844. View

Ghanbari Mehrabani M, Karimian R, Rakhshaei R, Pakdel F, Eslami H, Fakhrzadeh V . Chitin/silk fibroin/TiO bio-nanocomposite as a biocompatible wound dressing bandage with strong antimicrobial activity. Int J Biol Macromol. 2018; 116:966-976. DOI: 10.1016/j.ijbiomac.2018.05.102. View

Lopez-Iglesias C, Barros J, Ardao I, Gurikov P, Monteiro F, Smirnova I . Jet Cutting Technique for the Production of Chitosan Aerogel Microparticles Loaded with Vancomycin. Polymers (Basel). 2020; 12(2). PMC: 7077406. DOI: 10.3390/polym12020273. View

10.

Noh M, Muthukrishnan S, Kramer K, Arakane Y . A chitinase with two catalytic domains is required for organization of the cuticular extracellular matrix of a beetle. PLoS Genet. 2018; 14(3):e1007307. PMC: 5891080. DOI: 10.1371/journal.pgen.1007307. View

11.

Gilarska A, Lewandowska-Lancucka J, Horak W, Nowakowska M . Collagen/chitosan/hyaluronic acid - based injectable hydrogels for tissue engineering applications - design, physicochemical and biological characterization. Colloids Surf B Biointerfaces. 2018; 170:152-162. DOI: 10.1016/j.colsurfb.2018.06.004. View

12.

Masuoka K, Ishihara M, Asazuma T, Hattori H, Matsui T, Takase B . The interaction of chitosan with fibroblast growth factor-2 and its protection from inactivation. Biomaterials. 2004; 26(16):3277-84. DOI: 10.1016/j.biomaterials.2004.07.061. View

13.

Lopata A, Lehrer S . New insights into seafood allergy. Curr Opin Allergy Clin Immunol. 2009; 9(3):270-7. DOI: 10.1097/ACI.0b013e32832b3e6f. View

14.

Ghanbari Mehrabani M, Karimian R, Mehramouz B, Rahimi M, Kafil H . Preparation of biocompatible and biodegradable silk fibroin/chitin/silver nanoparticles 3D scaffolds as a bandage for antimicrobial wound dressing. Int J Biol Macromol. 2018; 114:961-971. DOI: 10.1016/j.ijbiomac.2018.03.128. View

15.

Wang S, Jayaram S, Hemphala J, Senti K, Tsarouhas V, Jin H . Septate-junction-dependent luminal deposition of chitin deacetylases restricts tube elongation in the Drosophila trachea. Curr Biol. 2006; 16(2):180-5. DOI: 10.1016/j.cub.2005.11.074. View

16.

Bernardes B, Del Gaudio P, Alves P, Costa R, Garcia-Gonzalez C, Oliveira A . Bioaerogels: Promising Nanostructured Materials in Fluid Management, Healing and Regeneration of Wounds. Molecules. 2021; 26(13). PMC: 8270285. DOI: 10.3390/molecules26133834. View

17.

Kumar V, Behr M, Kiritsi D, Scheffschick A, Grahnert A, Homberg M . Keratin-dependent thymic stromal lymphopoietin expression suggests a link between skin blistering and atopic disease. J Allergy Clin Immunol. 2016; 138(5):1461-1464.e6. DOI: 10.1016/j.jaci.2016.04.046. View

18.

Dirks J, Taylor D . Fracture toughness of locust cuticle. J Exp Biol. 2012; 215(Pt 9):1502-8. DOI: 10.1242/jeb.068221. View

19.

Tigli R, Gumusderelioglu M . Evaluation of RGD- or EGF-immobilized chitosan scaffolds for chondrogenic activity. Int J Biol Macromol. 2008; 43(2):121-8. DOI: 10.1016/j.ijbiomac.2008.04.003. View

20.

Liu X, Howard K, Dong M, Andersen M, Rahbek U, Johnsen M . The influence of polymeric properties on chitosan/siRNA nanoparticle formulation and gene silencing. Biomaterials. 2006; 28(6):1280-8. DOI: 10.1016/j.biomaterials.2006.11.004. View